An endoscopically compatible fast-gelation powder forms Janus-adhesive hydrogel barrier to prevent postoperative adhesions.
An endoscopically compatible fast-gelation powder forms Janus-adhesive hydrogel barrier to prevent postoperative adhesions.
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DOI：
10.1073/pnas.2219024120
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发表时间：
2023-02-07
影响因子：
11.1
通讯作者：
Xu, Feng
中科院分区：
文献类型：
--
作者：
Jia, Yuanbo;Feng, Jinteng;Feng, Zhe;Liu, Jingyi;Yang, Yanshen;Li, Xiaokang;Lei, Meng;Guo, Hui;Wei, Zhao;Lv, Yi;Xu, Feng
术后粘连是几乎所有外科手术的后遗症之一。理想的防粘连屏障应单侧粘附于组织上，并与内窥镜外科手术兼容。本研究开发了一种具有快速吸水和快速凝胶能力的FJG粉末。Janus水凝胶屏障可以通过用不同溶液逐步水合FJG粉末来形成。硼酸盐交联粘弹性水凝胶具有良好的组织顺应性，可用于不同运动模式的器官的防粘连屏障。最重要的是，FJG粉末易于储存，并且可以使用低成本的输送装置应用于内窥镜手术。这些结果强调了FJG粉末用于临床转化的巨大潜力。术后粘连广泛发生于各种组织，带来二次手术的风险，增加医疗负担。具有Janus粘附能力的水凝胶屏障可以实现邻近组织的物理隔离，因此被认为是理想的解决方案。然而，整合内窥镜递送便利性和粘弹性Janus水凝胶形成仍然是一个巨大的挑战。在这里，我们提出了一份报告，在原位形成的Janus粘附性水凝胶屏障使用喷雾快速Janus凝胶化（FJG）粉末。我们首先将多糖大分子甲基丙烯酸酯化以破坏分子间氢键并赋予快速水合的能力。FJG粉末能迅速吸收界面水，并通过硼酸酯键交联，形成具有韧性的粘弹性水凝胶。Janus屏障可以简单地通过用阳离子溶液进一步水合上层粉末来形成。我们构建大鼠模型以证明粘弹性FJG水凝胶在具有不同运动模式（例如，肠、心脏、肝脏）。我们还开发了一种具有标准化手术程序的低成本输送装置，并使用临床前转化猪模型进一步验证了FJG粉末在微创手术中的可行性和有效性。考虑到在治疗效果、临床便利性和商业化方面的优势，我们的研究结果揭示了Janus凝胶粉末材料作为下一代防粘连屏障的巨大潜力。
Postoperative adhesions are one of the sequelae of almost all surgical procedures. An ideal antiadhesion barrier should be unilaterally adhesive on tissue and compatible with the endoscopic surgical procedure. Here, we develop a FJG powder with rapid water absorption and fast gelation ability. The Janus hydrogel barriers can be formed by stepwise hydrating the FJG powder with different solutions. The borate cross-linked viscoelastic hydrogel with good tissue compliance can be used as antiadhesion barriers for organs with different motion modalities. Most importantly, FJG powder is easy to store and can be applied in endoscopic procedures with a low-cost delivery device. These results emphasize the great potential of FJG powder for clinical translation. Postoperative adhesions occur widely in various tissues, bringing the risk of secondary surgery and increased medical burden. Hydrogel barriers with Janus-adhesive ability can achieve physical isolation of adjacent tissues and are therefore considered an ideal solution. However, integrating endoscopic delivery convenience and viscoelastic Janus hydrogel formation remains a great challenge. Here, we present a report of the in situ formation of Janus-adhesive hydrogel barrier using a sprayable fast-Janus-gelation (FJG) powder. We first methacrylate the polysaccharide macromolecules to break the intermolecular hydrogen bonds and impart the ability of rapid hydration. FJG powder can rapidly absorb interfacial water and crosslink through borate ester bonds, forming a toughly adhesive viscoelastic hydrogel. The Janus barrier can be simply formed by further hydrating the upper powder with cationic solution. We construct rat models to demonstrate the antiadhesions efficiency of viscoelastic FJG hydrogels in organs with different motion modalities (e.g., intestine, heart, liver). We also developed a low-cost delivery device with a standardized surgical procedure and further validated the feasibility and effectiveness of FJG powder in minimally invasive surgery using a preclinical translational porcine model. Considering the advantages in terms of therapeutic efficacy, clinical convenience, and commercialization, our results reveal the great potential of Janus-gelation powder materials as a next-generation antiadhesions barrier.
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影响因子：
4.6
作者：
Di Filippo C;Falsetto A;De Pascale V;Tufariello E;De Lucia D;Rossi F;D'Amico M;Cennamo A
通讯作者：
Cennamo A
影响因子：
13.6
作者：
Blacklow, S. O.;Li, J.;Mooney, D. J.
通讯作者：
Mooney, D. J.
DOI：
10.1126/science.aah6362
发表时间：
2017-07-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li J;Celiz AD;Yang J;Yang Q;Wamala I;Whyte W;Seo BR;Vasilyev NV;Vlassak JJ;Suo Z;Mooney DJ
通讯作者：
Mooney DJ
DOI：
10.5114/wiitm.2011.34884
发表时间：
2013-12
期刊：
Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques
影响因子：
--
作者：
Banasiewicz T;Horbacka K;Karoń J;Malinger S;Antos F;Rudzki S;Kala Z;Stojcev Z;Kössi J;Krokowicz P
通讯作者：
Krokowicz P
一种治疗心肌梗死的粘弹性粘性心外膜补片
影响因子：
28.1
作者：
Lin, Xiao;Liu, Yue;Gao, Huajian
通讯作者：
Gao, Huajian