Rapid and continuous modulation of hippocampal network state during exploration of new places.
Rapid and continuous modulation of hippocampal network state during exploration of new places.
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DOI：
10.1371/journal.pone.0073114
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Frank LM
中科院分区：
文献类型：
--
作者：
Kemere C;Carr MF;Karlsson MP;Frank LM
海马区的信息加工通常被描述为两种状态，在运动时处于位置细胞状态，在静止时处于重新激活状态。对于网络在探索过程中如何在这些不同的活动模式之间转换，我们知之甚少。在这里，我们展示了随着动物探索并熟悉最初的新地方，海马体网络迅速而持续地变化。我们测量了大鼠行为的瞬间变化与通过海马区CA1区的信息流之间的关系。我们检查了局域场电位(LFP)模式、诱发电位和整体棘波，发现有证据表明，从低速时CA1活动的强烈CA3驱动平稳过渡到较高速度时CA1活动的内嗅皮层驱动。这些变化是在不到一秒的时间尺度上发生行为变化的，这表明作为行为状态的函数，海马体回路中的信息处理不断地进行调制。
Hippocampal information processing is often described as two-state, with a place cell state during movement and a reactivation state during stillness. Relatively little is known about how the network transitions between these different patterns of activity during exploration. Here we show that hippocampal network changes quickly and continuously as animals explore and become familiar with initially novel places. We measured the relationship between moment-by-moment changes in behavior and information flow through hippocampal output area CA1 in rats. We examined local field potential (LFP) patterns, evoked potentials and ensemble spiking and found evidence suggestive of a smooth transition from strong CA3 drive of CA1 activity at low speeds to entorhinal cortical drive of CA1 activity at higher speeds. These changes occurred with changes in behavior on a timescale of less than a second, suggesting a continuous modulation of information processing in the hippocampal circuit as a function of behavioral state.
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影响因子：
16.2
作者：
Carr MF;Karlsson MP;Frank LM
通讯作者：
Frank LM
DOI：
10.1523/jneurosci.5110-11.2012
发表时间：
2012-05-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ahmed OJ;Mehta MR
通讯作者：
Mehta MR
影响因子：
3.5
作者：
Berke, Joshua D.;Hetrick, Vaughn;Greene, Robert W.
通讯作者：
Greene, Robert W.
影响因子：
16.2
作者：
Gu Z;Yakel JL
通讯作者：
Yakel JL
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G