No correlation between multi‐locus heterozygosity and fitness in the common buzzard despite heterozygote advantage for plumage colour

No correlation between multi‐locus heterozygosity and fitness in the common buzzard despite heterozygote advantage for plumage colour
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尽管羽毛颜色具有杂合优势,但普通秃鹰的多位点杂合性和健康度之间没有相关性

DOI:
10.1111/jeb.12221
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发表时间:
2013
影响因子:
2.1
通讯作者:
Krüger
Krüger
中科院分区:
生物学3区
文献类型:
--
作者:
Boerner;Hoffman;Chakarov;Krüger

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杂合性和适合度之间的相关性经常被发现,但很少被充分理解。适应性可能受到大效应的单个基因座的影响,这些基因座通过连锁不平衡与中性标记相关,或者是近亲繁殖后全基因组杂合性变化的结果。我们在普通秃鹰中探索了这些替代方案,普通秃鹰是一种猛禽,其中三种颜色的变形在一生中的繁殖成功率有所不同。使用 18 个多态性微卫星位点,我们评估了可能导致亚群结构的形态之间的潜在遗传差异,并测试了三个与健康相关的性状和杂合性之间的相关性,包括全基因组和每个位点。尽管秃鹰的交配模式多种多样,但人们发现它们在基因上没有分化。研究发现,多位点杂合性仅与单一健康相关性状(血液寄生虫布氏白细胞虫感染)相关,并且这是通过与田鼠丰度和年龄的相互作用实现的。一个位点还显示出与血液寄生虫感染和体外寄生虫感染存在显着关系。该基因座附近包含两个基因,其中之一可能与鸟类的免疫系统有关。我们的结论是,全基因组杂合性不太可能成为多态秃鹰寄生虫负担和身体状况的主要决定因素。
Correlations between heterozygosity and fitness are frequently found but rarely well understood. Fitness can be affected by single loci of large effect which correlate with neutral markers via linkage disequilibrium, or as a result of variation in genome‐wide heterozygosity following inbreeding. We explored these alternatives in the common buzzard, a raptor species in which three colour morphs differ in their lifetime reproductive success. Using 18 polymorphic microsatellite loci, we evaluated potential genetic differences among the morphs which may lead to subpopulation structuring and tested for correlations between three fitness‐related traits and heterozygosity, both genome wide and at each locus separately. Despite their assortative mating pattern, the buzzard morphs were found to be genetically undifferentiated. Multilocus heterozygosity was only found to be correlated with a single fitness‐related trait, infection with the blood parasite,Leucocytozoon buteonis, and this was via interactions with vole abundance and age. One locus also showed a significant relationship with blood parasite infection and ectoparasite infestation. The vicinity of this locus contains two genes, one of which is potentially implicated in the immune system of birds. We conclude that genome‐wide heterozygosity is unlikely to be a major determinant of parasite burden and body condition in the polymorphic common buzzard.
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