Th17 cytokines and host-pathogen interactions at the mucosa: dichotomies of help and harm.
Th17 cytokines and host-pathogen interactions at the mucosa: dichotomies of help and harm.
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DOI：
10.1016/j.cyto.2009.07.005
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发表时间：
2009-10
期刊：
影响因子：
3.8
通讯作者：
Raffatellu, Manuela
中科院分区：
文献类型：
--
作者：
Liu, Janet Z.;Pezeshki, Milad;Raffatellu, Manuela
粘膜表面通常是病原微生物与宿主相互作用的第一个部位。粘膜免疫反应的激活具有遏制感染和防止病原体传播到全身部位的重要功能(屏障功能)。大量证据表明，屏障功能是由属于Th17家族的细胞因子(白介素17和白介素22)的子集协调的。IL-17和IL-22诱导黏膜部位抗菌肽和中性粒细胞趋化因子的表达，在控制黏膜感染中发挥重要作用。然而，越来越多的证据表明，黏膜病原体在炎症过程中实现了更大的定植，因为它们对这些抗菌反应的子集具有耐药性。在这篇综述中，我们比较了Th17细胞因子在四种不同病原体：肺炎克雷伯菌、轮状柠檬酸杆菌、白色念珠菌和鼠伤寒沙门氏菌的粘膜感染中所引起的抗菌反应。然后我们将讨论哪些反应可能构成粘膜屏障，从而为宿主提供好处，以及哪些反应可能促进病原体的定植，从而为微生物提供好处。
The mucosal surfaces are often the first site of interaction between pathogenic microorganisms and the host. Activation of the mucosal immune response has the important function of containing an infection and preventing dissemination of pathogens to systemic sites (barrier function). Numerous lines of evidence suggest that the barrier function is orchestrated by a subset of cytokines (interleukin (IL-)17 and IL-22), which belong to the Th17 family. IL-17 and IL-22 induce expression of antimicrobial peptides and neutrophil chemoattractants at mucosal sites, and thus play an important role in controlling mucosal infections. However, there is increasing evidence that mucosal pathogens achieve greater colonization during inflammation because they are resistant to a subset of these antimicrobial responses. In this review we compare the antimicrobial responses elicited by Th17 cytokines during mucosal infections with four different pathogens: Klebsiella pneumoniae, Citrobacter rodentium, Candida albicans and Salmonella typhimurium. We will then discuss which responses may constitute the mucosal barrier, thus providing a benefit to the host, and which ones may promote the colonization of pathogens, thereby providing a benefit to the microbes.
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影响因子：
64.8
作者：
Brandl, Katharina;Plitas, George;Mihu, Coralia N.;Ubeda, Carles;Jia, Ting;Fleisher, Martin;Schnabl, Bernd;DeMatteo, Ronald P.;Pamer, Eric G.
通讯作者：
Pamer, Eric G.
影响因子：
3.6
作者：
Crouch, Marie-Laure V.;Castor, Margaret;Fang, Ferric C.
通讯作者：
Fang, Ferric C.
DOI：
10.1073/pnas.0510847103
发表时间：
2006-02-07
影响因子：
11.1
作者：
Berger, T;Togawa, A;Mak, TW
通讯作者：
Mak, TW
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
4.8
作者：
Chen, Y;Thai, P;Wu, R
通讯作者：
Wu, R