Development of "Hunger Neurons" and the Unanticipated Relationship Between Energy Metabolism and Mother-Infant Interactions.
Development of "Hunger Neurons" and the Unanticipated Relationship Between Energy Metabolism and Mother-Infant Interactions.
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DOI：
10.1016/j.biopsych.2022.02.962
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发表时间：
2022-05-15
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在人的一生中，围产期在生理系统的功能中发挥着巨大的作用。在这里，我们讨论如何调节能量代谢的神经元有助于婴儿与母亲的关系。我们集中我们的讨论Agrp神经元，这是位于下丘脑弓状核。这些神经元严重调节能量代谢。由于后代过渡时期的依赖照顾者的独立，我们讨论的重要性，后代的关系，Agrp神经元的功能。我们目前的证据表明，在成年人，Agrp神经元激励动物吃，而在新生儿，他们激励后代寻求接近照顾者。我们特别强调了Agrp神经元发育的特点，以及它们如何与一生中代谢和行为的调节有关。总之，这篇评论认为，个体发育研究可以提供对我们的理解复杂的生物系统，如调节能量代谢和母婴依恋的独特见解。
Over the course of a lifetime, the perinatal period plays an outsized role in the function of physiological systems. Here, we discuss how neurons that regulate energy metabolism contribute to the infant’s relationship with the mother. We focus our discussion on Agrp neurons, which are located in the arcuate nucleus of the hypothalamus. These neurons heavily regulate energy metabolism. Because offspring transition from a period of dependence on the caregiver to independence, we discuss the importance of the caregiver-offspring relationship for the function of Agrp neurons. We present evidence that, in the adult, Agrp neurons motivate the animal to eat, while, in the neonate, they motivate the offspring to seek the proximity of the caregiver. We specifically highlight the peculiarities in the development of Agrp neurons and how they relate to the regulation of metabolism and behavior over the course of a lifetime. In sum, this review considers the unique insights that ontogenetic studies can offer toward our understanding of complex biological systems, such as the regulation of energy metabolism and mother-infant attachment.
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影响因子：
64.5
作者：
Dietrich MO;Zimmer MR;Bober J;Horvath TL
通讯作者：
Horvath TL
影响因子：
29
作者：
Denis RG;Joly-Amado A;Webber E;Langlet F;Schaeffer M;Padilla SL;Cansell C;Dehouck B;Castel J;Delbès AS;Martinez S;Lacombe A;Rouch C;Kassis N;Fehrentz JA;Martinez J;Verdié P;Hnasko TS;Palmiter RD;Krashes MJ;Güler AD;Magnan C;Luquet S
通讯作者：
Luquet S
影响因子：
8.1
作者：
Juan De Solis A;Baquero AF;Bennett CM;Grove KL;Zeltser LM
通讯作者：
Zeltser LM
影响因子：
25
作者：
Dietrich, Marcelo O.;Bober, Jeremy;Horvath, Tamas L.
通讯作者：
Horvath, Tamas L.
影响因子：
16.6
作者：
Cavalcanti-de-Albuquerque, Joao Paulo;Bober, Jeremy;Dietrich, Marcelo O.
通讯作者：
Dietrich, Marcelo O.