Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding.
Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding.
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DOI：
10.1016/j.cell.2015.02.024
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发表时间：
2015-03-12
期刊：
影响因子：
64.5
通讯作者：
Horvath TL
中科院分区：
文献类型：
--
作者：
Dietrich MO;Zimmer MR;Bober J;Horvath TL
神经系统通过整合内感受和感觉信息来协调灵活的目标导向行为。已知下丘脑Agrp神经元对摄食行为至关重要。然而，在这里，我们表明这些神经元也协调成年小鼠的其他复杂行为。在没有食物的情况下，Agrp神经元的激活触发觅食和重复行为，这些行为通过食物消耗而恢复。这些由Agrp神经元触发的刻板行为与焦虑减少相结合。NPY 5受体信号传导是Agrp神经元激活后介导重复行为所必需的，而对摄食的影响较小。因此，我们揭示了Agrp神经元在控制重复行为介导的功能作用，至少部分是由神经肽能信号。这些发现揭示了一组与能量稳态回路相关联的新行为，并为刻板行为疾病提供了潜在的治疗途径。
The nervous system evolved to coordinate flexible goal-directed behaviors by integrating interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial for feeding behavior. Here, however, we show that these neurons also orchestrate other complex behaviors in adult mice. Activation of Agrp neurons in the absence of food triggers foraging and repetitive behaviors, which are reverted by food consumption. These stereotypic behaviors that are triggered by Agrp neurons are coupled with decreased anxiety. NPY5 receptor signaling is necessary to mediate the repetitive behaviors after Agrp neuron activation while having minor effects on feeding. Thus, we have unmasked a functional role for Agrp neurons in controlling repetitive behaviors mediated, at least in part, by neuropeptidergic signaling. The findings reveal a new set of behaviors coupled to the energy homeostasis circuit and suggest potential therapeutic avenues for diseases with stereotypic behaviors.
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