The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder.
The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder.
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DOI：
10.1002/gps.4048
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发表时间：
2014-06
影响因子：
4
通讯作者：
Gildengers, Ariel G.
中科院分区：
文献类型：
--
作者：
Lotrich, Francis E.;Butters, Meryl A.;Aizenstein, Howard;Marron, Megan M.;Reynolds, Charles F., III;Gildengers, Ariel G.
关键词：
认知障碍是双相情感障碍（BD）的一个特征，并可能因炎症细胞因子而恶化。我们确定(i)老年BD受试者血清白细胞介素-1受体拮抗剂（IL-1RA）是否升高，（ii） IL-1RA是否与神经认知功能恶化有关，以及（iii） IL-1RA是否与白质完整性有关。21例血清可用于酶联免疫测定IL-1RA的健全性BD患者（65 +/ - 9岁）与26例年龄相仿的对照组进行了比较。从21个神经认知测试中获得了四因素分析衍生的z分数和全局z分数。采用扩散张量图像获得分数各向异性（FA），采用自动标记路径算法获得白质高强度（WMH）负荷。与对照组相比，BD患者IL-1RA升高（439+/ - 326 pg/mL vs. 269+/ - 109 pg/mL; p=0.004）。IL-1RA与三项认知功能因子及整体认知呈负相关（r= - 0.37; p=0.01）。即使IL-6或脑源性神经营养因子（BDNF）共变，IL-1RA仍与整体认知功能相关。虽然BD患者的FA较低（0.368 +/ - 0.02 vs 0.381 +/ - 0.01; p= 0.02），但IL-1RA与FA或WMH负担无关。双相障碍患者血清IL-1RA水平升高与认知功能恶化相关，即使在心境良好的情况下也是如此。这种关联不能用同时发生的IL-6升高、BDNF降低或白质完整性测量来解释。这些横断面研究结果支持IL-1家族可能导致双相障碍患者认知障碍的可能性。
Cognitive impairments are a feature of bipolar disorder (BD) and could be worsened by inflammatory cytokines. We determined whether (i) serum interleukin-1 receptor antagonist (IL-1RA) was increased in elderly BD subjects, (ii) whether IL-1RA was associated with worse neurocognitive function, and (iii) whether IL-1RA was associated with white matter integrity. 21 euthymic BD patients (65 +/− 9 years) with serum available for IL-1RA measures by enzyme-linked immunoassays were compared with 26 similarly aged control participants. Four factor analysis-derived z-scores and a global z-score were obtained from a battery of 21 neurocognitive tests. Diffusion Tensor Images were used to obtain fractional anisotropy (FA), and an Automated Labeling Pathway algorithm was used to obtain white matter hyperintensity (WMH) burden. IL-1RA was elevated in BD subjects compared to controls (439+/−326 pg/mL vs. 269+/−109 pg/mL; p=0.004). Moreover, IL-1RA was inversely correlated with three cognitive function factors and global cognition (r=−0.37; p=0.01). IL-1RA continued to correlate with global cognitive function even when co-varying for either IL-6 or brain-derived neurotrophic factor (BDNF). Although FA was lower in BD subjects (0.368 +/− 0.02 vs. 0.381 +/− 0.01; p=.02), IL-1RA was not associated with FA or WMH burden. Elevated serum levels of IL-1RA in BD subjects, even during euthymic states, were associated with worse cognitive function. This association was not explained by co-occurring increases in IL-6, by decreased BDNF, nor by measures of white matter integrity. These cross-sectional findings support the possibility that the IL-1 family may contribute to cognitive impairments in BD.
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DOI：
10.4049/jimmunol.1102624
发表时间：
2012-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Corbett GT;Roy A;Pahan K
通讯作者：
Pahan K
DOI：
10.1523/jneurosci.2173-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barrientos RM;Hein AM;Frank MG;Watkins LR;Maier SF
通讯作者：
Maier SF
影响因子：
5.5
作者：
Cartmell, T;Luheshi, GN;Poole, S
通讯作者：
Poole, S
影响因子：
4
作者：
Delaloye, C.;Moy, G.;Giannakopoulos, P.
通讯作者：
Giannakopoulos, P.
影响因子：
15.1
作者：
Abraham, Jayne;Johnson, Rodney W.
通讯作者：
Johnson, Rodney W.