Jak/Stat signaling regulates the proliferation and neurogenic potential of Müller glia-derived progenitor cells in the avian retina.
Jak/Stat signaling regulates the proliferation and neurogenic potential of Müller glia-derived progenitor cells in the avian retina.
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DOI：
10.1038/srep35703
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发表时间：
2016-10-19
影响因子：
4.6
通讯作者：
Fischer AJ
中科院分区：
文献类型：
--
作者：
Todd L;Squires N;Suarez L;Fischer AJ
Müller glia are capable of de-differentiating and proliferating to become Müller glia-derived progenitor cells (MGPCs) with the ability to regenerate retinal neurons. One of the cell-signaling pathways that drives the reprogramming of Müller glia into MGPCs in the zebrafish retina is the Jak/Stat-pathway. However, nothing is known about the influence of Jak/Stat-signaling during the formation of MGPCs in the retinas of warm-blooded vertebrates. Accordingly, we examined whether Jak/Stat-signaling influences the formation of MGPCs and differentiation of progeny in the avian retina. We found that Jak/Stat-signaling is activated in Müller glia in response to NMDA-induced retinal damage or by CNTF or FGF2 in the absence of retinal damage. Inhibition of gp130, Jak2, or Stat3 suppressed the formation of proliferating MGPCs in NMDA-damaged and FGF2-treated retinas. Additionally, CNTF combined with FGF2 enhanced the formation of proliferating MGPCs in the absence of retinal damage. In contrast to the zebrafish model, where activation of gp130/Jak/Stat is sufficient to drive neural regeneration from MGPCs, signaling through gp130 inhibits the neurogenic potential of MGPCs and promotes glial differentiation. We conclude that gp130/Jak/Stat-signaling plays an important role in the network of pathways that drives the formation of proliferating MGPCs; however, this pathway inhibits the neural differentiation of the progeny.
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影响因子：
6.2
作者：
Fischer, Andy J.;Scott, Melissa A.;Zelinka, Christopher;Sherwood, Patrick
通讯作者：
Sherwood, Patrick
影响因子：
4.7
作者：
Ghai K;Zelinka C;Fischer AJ
通讯作者：
Fischer AJ
DOI：
10.1073/pnas.1107488109
发表时间：
2012-03-20
影响因子：
11.1
作者：
de Melo, Jimmy;Miki, Katsuaki;Blackshaw, Seth
通讯作者：
Blackshaw, Seth
影响因子：
25
作者：
Fischer, AJ;Reh, TA
通讯作者：
Reh, TA
影响因子：
56.9
作者：
Bonni, A;Sun, Y;Greenberg, ME
通讯作者：
Greenberg, ME