A dedicated breast-PET/CT scanner: Evaluation of basic performance characteristics.
A dedicated breast-PET/CT scanner: Evaluation of basic performance characteristics.
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DOI：
10.1002/mp.12780
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发表时间：
2018-04
期刊：
影响因子：
3.8
通讯作者：
Perna M
中科院分区：
文献类型：
--
作者：
Raylman RR;Van Kampen W;Stolin AV;Gong W;Jaliparthi G;Martone PF;Smith MF;Sarment D;Clinthorne NH;Perna M
应用先进的成像技术，如PET和X射线CT，可以潜在地提高乳腺癌的检测。不幸的是，这两种模式在检测某些病变方面都存在挑战。然而，这两种技术的结合可能会导致诊断乳腺成像的整体改善。本研究的目的是测试一种新的专用乳腺PET/CT的基本性能。PET组件由一对旋转探测器组成。其性能使用NEMA NU 4 -2008协议进行评估。CT组件利用与PET扫描仪安装在同一台架上的脉冲X射线源和平板探测器。其性能使用专门的幻影进行评估。通过测量16 cm直径PMMA圆柱体中心的自由空气比释动能和空气比释动能，探讨CT成像期间乳房的辐射剂量。最后，该系统的综合能力，证明了微型热棒幻影成像。总体而言，PET组件的性能非常好，与许多临床前和其他专用乳房PET扫描仪相当。其空间分辨率为2.2 mm，距离扫描仪中心5 mm，使用单切片滤波反投影算法创建的图像。峰值NECR为24.6 kcps;峰值灵敏度为1.36%;散射分数为27%。CT扫描仪的空间分辨率为1.1 lp/mm（10% MTF）。自由空气比释动能为2.33 mGy，而PMMA-空气比释动能为1.24 mGy。最后，一个微型热棒体模的组合成像说明了由该系统产生的双模态图像的良好质量和潜在的实用性。新型乳腺专用PET/CT扫描仪的基本性能特征良好，表明其性能与当前专用PET和CT扫描仪相似。该系统的潜在价值是能够产生组合的双模态图像，可以提高乳腺疾病的检测。该系统开发的下一阶段是用更先进的幻影和人类受试者进行测试。
Application of advanced imaging techniques, such as PET and x-ray CT, can potentially improve detection of breast cancer. Unfortunately, both modalities have challenges in the detection of some lesions. The combination of the two techniques, however, could potentially lead to an overall improvement in diagnostic breast imaging. The purpose of this investigation is to test the basic performance of a new dedicated breast-PET/CT. The PET component consists of a rotating pair of detectors. Its performance was evaluated using the NEMA NU4-2008 protocols. The CT component utilizes a pulsed x-ray source and flat panel detector mounted on the same gantry as the PET scanner. Its performance was assessed using specialized phantoms. The radiation dose to a breast during CT imaging was explored by the measurement of free-in-air kerma and air kerma measured at the center of a 16 cm-diameter PMMA cylinder. Finally, the combined capabilities of the system were demonstrated by imaging of a micro-hot-rod phantom. Overall, performance of the PET component is very good, comparable to many pre-clinical and other dedicated breast-PET scanners. Its spatial resolution is 2.2 mm, 5 mm from the center of the scanner using images created with the single-sliced-filtered-backprojection algorithm. Peak NECR is 24.6 kcps; peak sensitivity is 1.36%; the scatter fraction is 27%. Spatial resolution of the CT scanner is 1.1 lp/mm at 10% MTF. The free-in-air kerma is 2.33 mGy, while the PMMA-air kerma is 1.24 mGy. Finally, combined imaging of a micro-hot-rod phantom illustrated the good quality and potential utility of the dual-modality images produced by the system. The basic performance characteristics of a new dedicated breast-PET/CT scanner are good, demonstrating that its performance is similar to current dedicated PET and CT scanners. The potential value of this system is the capability to produce combined duality-modality images that could improve detection of breast disease. The next stage in development of this system is testing with more advanced phantoms and human subjects.
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