Behavioral and neurophysiologic response to therapy for chronic aphasia.
Behavioral and neurophysiologic response to therapy for chronic aphasia.
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DOI：
10.1016/j.apmr.2009.08.144
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发表时间：
2009-12
影响因子：
4.3
通讯作者：
Papanicolaou, Andrew C.
中科院分区：
文献类型：
--
作者：
Breier, Joshua I.;Juranek, Jenifer;Maher, Lynn M.;Schmadeke, Stephanie;Men, Disheng;Papanicolaou, Andrew C.
应用脑磁图（MEG）研究脑神经生理变化与约束诱导语言治疗（CILT）行为反应的关系。系列。医学院。左半球首次单侧脑卒中后慢性失语患者23例。限制性语言治疗每周4次，每次3小时，持续3周。在CILT之前、之后和之后3个月使用MEG进行语言理解任务中的语言测试和功能成像，并在CILT前3周接受额外的MEG扫描和语言测试的患者亚组。正确信息单元的百分比和后期偶极子的数量归一化到总激活。确定了对CILT的三种行为和神经生理反应模式。在CILT后立即语言能力有显著改善的患者在随访中失去了这些改善，在所有MEG扫描过程中，他们的右半球活动都比其他患者大。在CILT后立即语言能力有显著改善的患者在随访中保持了这些改善，在CILT后左颞叶激活增加，而在CILT后语言能力没有显著改善的患者在左顶叶区表现出相对更大的激活。结果表明，虽然右半球可能支持治疗后语言功能的恢复，但这种恢复可能不稳定，并且左半球病变周围区域的一些参与可能是稳定行为反应所必需的。
To characterize the relationship between neurophysiologic changes in the brain and behavioral response to constraint-induced language therapy (CILT) by using magnetoencephalography (MEG). Case series. Medical school. Patients (N = 23) with chronic aphasia after first-time unilateral stroke in the left hemisphere. Constraint-induced language therapy administered for 3 hours 4 times per week for 3 weeks. Language testing and functional imaging during a language comprehension task using MEG before, immediately after, and 3 months after CILT with a subgroup of patients undergoing additional MEG scanning and language testing 3 weeks before CILT. The percent of correct information units and the number of late dipoles normalized to total activation. Three patterns of behavioral and neurophysiologic response to CILT were identified. Patients with significant improvement in language immediately after CILT who lost these gains at follow-up had greater right hemisphere activation than other patients at all MEG scanning sessions. Patients with significant improvement in language immediately after CILT who maintained these gains at follow-up exhibited an increase in left temporal activation after CILT, whereas patients who did not exhibit significant improvement in language after CILT exhibited comparably greater activation in left parietal areas. Results suggest that although the right hemisphere may support recovery of language function in response to therapy, this recovery may not be stable, and some participation of perilesional areas of the left hemisphere may be necessary for a stable behavioral response.
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影响因子：
2.6
作者：
FRITH, CD;FRISTON, KJ;FRACKOWIAK, RSJ
通讯作者：
FRACKOWIAK, RSJ
影响因子：
5.7
作者：
Meinzer, Marcus;Flaisch, Tobias;Rockstroh, Brigitte
通讯作者：
Rockstroh, Brigitte
DOI：
10.1076/jcen.20.6.782.1116
发表时间：
1998-12-01
影响因子：
2.2
作者：
Breier, JI;Simos, PG;Papanicolaou, AC
通讯作者：
Papanicolaou, AC
影响因子：
2
作者：
Fridriksson, J;Morrow, L
通讯作者：
Morrow, L
影响因子：
11.2
作者：
Blank, SC;Bird, H;Wise, RJS
通讯作者：
Wise, RJS