Epigenomics of Alzheimer's disease.
Epigenomics of Alzheimer's disease.
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DOI：
10.1016/j.trsl.2014.05.006
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
De Jager PL
中科院分区：
文献类型：
--
作者：
Bennett DA;Yu L;Yang J;Srivastava GP;Aubin C;De Jager PL
阿尔茨海默病(AD)是一个巨大且日益严重的公共卫生问题。它的特征是淀粉样蛋白-β多肽和异常磷酸化的tau蛋白积累，这与认知能力下降和痴呆有关。从连锁分析和最近的全基因组关联研究中，人们对AD的基因组学有了很多了解。基因组图谱的几个方面(但不是所有方面)都与淀粉样蛋白代谢有关。双胞胎之间疾病的中等一致性表明，其他因素，潜在的表观遗传因素，与AD有关。我们正处于检查表观基因组与阿尔茨海默病的临床和病理表型的关系的最早阶段。我们的文献回顾表明，有一些证据表明，人类大脑甲基化发生了与年龄相关的变化。不幸的是，对AD的研究相对较少，对甲基化位点和microRNA的覆盖有限，更不用说其他表观基因组标记了。我们正在对人脑进行两项大型研究，其中包括用Illumina Infinium Humanmylation450K珠阵对超过420,000个常染色体胞嘧啶-鸟嘌呤二核苷酸(CGs)进行研究，以及用染色质免疫沉淀-测序法对组蛋白进行乙酰化。我们提供描述性数据，以帮助告知其他研究人员从这些方法中期待什么，以便更好地设计和支持他们的研究。然后，我们讨论了未来的方向，以了解AD的表观基因组结构。
Alzheimer’s disease (AD) is a large and growing public health problem. It is characterized by the accumulation of amyloid-β peptides and abnormally phosphorylated tau proteins that are associated with cognitive decline and dementia. Much has been learned about the genomics of AD from linkage analyses and more recently, genome-wide association studies. Several but not all aspects of the genomic landscape are involved in amyloid-metabolism. The moderate concordance of disease among twins suggests other factors, potentially epigenomic factors, are related to AD. We are at the earliest stages of examining the relation of the epigenome to the clinical and pathologic phenotypes that characterize AD. Our literature review suggests that there is some evidence of age-related changes in human brain methylation. Unfortunately, studies of AD have been relatively small with limited coverage of methylation sites and microRNA, let alone other epigenomic marks. We are in the midst of two large studies of human brains including coverage of more than 420,000 autosomal cytosine-guanine dinucleotides (CGs) with the Illumina Infinium HumanMethylation 450K BeadArray, and histone acetylation with chromatin immunoprecipitation-sequencing. We present descriptive data to help inform other researchers what to expect from these approaches in order to better design and power their studies. We then discuss future directions to inform on the epigenomic architecture of AD.
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影响因子：
11.2
作者：
Bennett, David A.;Wilson, Robert S.;Boyle, Patricia A.;Buchman, Aron S.;Schneider, Julie A.
通讯作者：
Schneider, Julie A.
影响因子：
9.9
作者：
Biffi, A.;Shulman, J. M.;Rosand, J.
通讯作者：
Rosand, J.
影响因子：
9.9
作者：
Bennett, David A.;De Jager, Philip L.;Schneider, Julie A.
通讯作者：
Schneider, Julie A.
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Albert MS;DeKosky ST;Dickson D;Dubois B;Feldman HH;Fox NC;Gamst A;Holtzman DM;Jagust WJ;Petersen RC;Snyder PJ;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH
DOI：
10.1097/nen.0b013e3181af2e46
发表时间：
2009-08-01
影响因子：
3.2
作者：
Barrachina, Marta;Ferrer, Isidre
通讯作者：
Ferrer, Isidre