Relation of neuropathology to cognition in persons without cognitive impairment.
Relation of neuropathology to cognition in persons without cognitive impairment.
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DOI：
10.1002/ana.23654
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发表时间：
2012-10
影响因子：
11.2
通讯作者：
Schneider, Julie A.
中科院分区：
文献类型：
--
作者：
Bennett, David A.;Wilson, Robert S.;Boyle, Patricia A.;Buchman, Aron S.;Schneider, Julie A.
检查阿尔茨海默病（AD）病理学、脑梗死和路易体（LB）病理学与无认知障碍人群认知的关系。来自两项老龄化队列研究（宗教秩序研究和记忆与老龄化项目）的无痴呆症患者同意每年进行临床评估和大脑捐赠。这些研究共有19项神经心理学表现测试，评估了五个认知领域。在296名死亡并接受尸检评估的无认知障碍的人中，我们将AD病理学量化为整体病理学评分，并量化为淀粉样蛋白负荷和PHFtau缠结密度、脑梗死和LB病理学。线性回归用于检查神经病理学与控制人口统计学的认知能力的关系。几乎所有的人都有AD病理学，超过四分之三的人表现出淀粉样蛋白; 22%的宏观和24%的微观梗死，13%的LB病理学。AD病理学的整体测量与整体认知相关（p=0.008），而梗死和路易体则无关。淀粉样蛋白负荷与整体认知相关（p<0.05），仅缠结有趋势（p=0.08）。在认知领域分析中，AD病理学（p=0.006）、PHFtau缠结（p=0.03）和肉眼可见梗死（p=0.02）与情景记忆相关，具有淀粉样蛋白负荷趋势（p=0.06）; AD病理学（p=0.02）和淀粉样蛋白负荷（p=0.03）与工作记忆相关。在新皮质淀粉样蛋白和近中颞叶缠结的额外分析中，整体认知和情景记忆的发现更强。AD病理学和肉眼可见的梗死在无认知障碍的老年人中很常见，并与情景记忆和工作记忆有关。
Examine the relation of Alzheimer's disease (AD) pathology, cerebral infarcts, and Lewy body (LB) pathology to cognition in persons without cognitive impairment. Persons without dementia from two cohort studies of aging, the Religious Orders Study and the Memory and Aging Project, agreed to annual clinical evaluation and brain donation. The studies had 19 neuropsychological performance tests in common that assessed five cognitive domains. Of 296 persons without cognitive impairment who died and underwent post-mortem assessment, we quantified AD pathology as a global pathology score, and as amyloid load and PHFtau tangle density, cerebral infarcts and LB pathology. Linear regression was used to examine the relation of neuropathology to cognitive abilities controlling for demographics. Nearly all persons had AD pathology with more than three quarters exhibiting amyloid; 22% macroscopic and 24% microscopic infarctions, and 13% had LB pathology. The global measure of AD pathology was related to global cognition (p=0.008) whereas infarcts and Lewy bodies were not. Amyloid load was related to global cognition (p<0.05) with only a trend for tangles (p=0.08). In analyses of cognitive domains, AD pathology (p=0.006), PHFtau tangles (p=0.03), and macroscopic infarctions (p=0.02) were related to episodic memory with a trend for amyloid load (p=0.06); and AD pathology (p=0.02) and amyloid load (p=0.03) were related to working memory. Findings for global cognition and episodic memory were stronger in additional analyses with neocortical amyloid and mesial temporal tangles. AD pathology and macroscopic infarctions are common in older persons without cognitive impairment and related to episodic and working memory.
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DOI：
10.1007/s12031-011-9589-0
发表时间：
2011-11
期刊：
Journal of molecular neuroscience : MN
影响因子：
--
作者：
Dickson DW;Kouri N;Murray ME;Josephs KA
通讯作者：
Josephs KA
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
影响因子：
4
作者：
Abner, Erin L.;Kryscio, Richard J.;Nelson, Peter T.
通讯作者：
Nelson, Peter T.
影响因子：
9.9
作者：
Kantarci, K.;Lowe, V.;Jack, C. R., Jr.
通讯作者：
Jack, C. R., Jr.
影响因子：
9.9
作者：
Bennett, DA;Wilson, RS;Bienias, JL
通讯作者：
Bienias, JL