Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies.
Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies.
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DOI：
10.1007/s00784-021-04013-4
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发表时间：
2021-08
影响因子：
3.4
通讯作者：
Bottino MC
中科院分区：
文献类型：
--
作者：
Soares DG;Bordini EAF;Swanson WB;de Souza Costa CA;Bottino MC
本文就近年来生物材料介导的牙髓组织工程的研究进展作一综述。具体来说，我们的目标是强调生物材料平台的关键设计标准，有利于牙髓组织工程，讨论模型的临床前评估，并提出新的和创新的多功能策略，为临床翻译的承诺。本文全面概述了过去五年来的最新进展。详细地说，我们调查了再生牙髓生物学方面的文献，包括新的生物和生物材料方法，以及那些结合多种策略的方法，以获得更临床相关的模型。使用关键词“再生牙科学”、“牙髓再生”、“再生牙髓学”和“牙髓治疗”进行PubMed检索。在过去的五年里，再生牙科领域做出了重大贡献，这一点可以从大量的出版物中得到证明。我们选择了我们认为是逐步走向临床可翻译解决方案的典型研究。最后，我们展望了未来的牙髓再生策略及其临床翻译这一审查。目前的临床治疗缺乏功能性和可预测的牙髓再生，更侧重于治疗牙髓暴露的后果，而不是恢复健康的牙髓。在临床上，对安全、有效和易于使用的生物启发生物材料策略有很大的需求，临床医生渴望将其临床转化。特别是，我们把重点放在战略，结合联合收割机有利的血管生成，矿化，功能组织的形成，同时限制免疫反应，微生物感染的风险，牙髓坏死。
The aim of this review is to highlight recent progress in the field of biomaterials-mediated dental pulp tissue engineering. Specifically, we aim to underscore the critical design criteria of biomaterial platforms that are advantageous for pulp tissue engineering, discuss models for preclinical evaluation, and present new and innovative multifunctional strategies that hold promise for clinical translation. The current article is a comprehensive overview of recent progress over the last five years. In detail, we surveyed the literature in regenerative pulp biology, including novel biologic and biomaterials approaches, and those that combined multiple strategies, towards more clinically relevant models. PubMed searches were performed using the keywords: “regenerative dentistry,” “dental pulp regeneration,” “regenerative endodontics,” and “dental pulp therapy.” Significant contributions to the field of regenerative dentistry have been made in the last five years, as evidenced by a significant body of publications. We chose exemplary studies that we believe are progressive towards clinically translatable solutions. We close this review with an outlook towards the future of pulp regeneration strategies and their clinical translation. Current clinical treatments lack functional and predictable pulp regeneration and are more focused on the treatment of the consequences of pulp exposure, rather than the restoration of healthy dental pulp. Clinically, there is great demand for bioinspired biomaterial strategies that are safe, efficacious, and easy to use, and clinicians are eager for their clinical translation. In particular, we place emphasis on strategies that combine favorable angiogenesis, mineralization, and functional tissue formation, while limiting immune reaction, risk of microbial infection, and pulp necrosis.
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影响因子：
9
作者：
Athirasala A;Tahayeri A;Thrivikraman G;França CM;Monteiro N;Tran V;Ferracane J;Bertassoni LE
通讯作者：
Bertassoni LE
影响因子：
2.9
作者：
Campos, Daniela F. Duarte;Zhang, Siyuan;Esteves-Oliveira, Marcella
通讯作者：
Esteves-Oliveira, Marcella
影响因子：
4.1
作者：
Galler, Kerstin M.;Hartgerink, Jeffrey D.;D'Souza, Rena N.
通讯作者：
D'Souza, Rena N.
影响因子：
9.5
作者：
Dubey, Nileshkumar;Ferreira, Jessica A.;Bottino, Marco C.
通讯作者：
Bottino, Marco C.
影响因子：
9.7
作者：
Dubey, Nileshkumar;Ferreira, Jessica A.;Bottino, Marco C.
通讯作者：
Bottino, Marco C.