Spectrum of human T-cell lymphotropic virus type III infection in children. Recognition of symptomatic, asymptomatic, and seronegative patients.
Spectrum of human T-cell lymphotropic virus type III infection in children. Recognition of symptomatic, asymptomatic, and seronegative patients.
复制标题
儿童人类 T 细胞嗜淋巴细胞病毒 III 型感染谱。
DOI：
10.1001/jama.1986.03370170063036
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Robert C. Gallo
中科院分区：
文献类型：
--
作者：
Savita Pahwa;Mark H. Kaplan;Senih Fikrig;R. Pahwa;M. Sarngadharan;Mikuláš Popovič;Robert C. Gallo
本研究是为了深入了解儿童感染人类t细胞嗜淋巴病毒III型/淋巴结病相关病毒（HTLV-III/LAV）引起的临床谱和免疫紊乱。HTLV-III的血清p41抗原抗体和/或淋巴细胞中HTLV-III的直接证据被认为是HTLV-III/LAV感染的指示。在36例HTLV-III/LAV感染的儿童中，注意到广泛的临床谱，从无症状（7名儿童）到有症状，后者包括14名患有获得性免疫缺陷综合征的儿童。5例有症状的婴儿出现小头畸形。所有有症状的儿童和两名无症状的儿童均有免疫功能障碍。1例患儿出现泛低γ -球蛋白血症。2例HTLV-III抗体阴性的无症状儿童有HTLV-III感染的病毒学证据。所有被研究的20名母亲都是HTLV-III抗体阳性，有免疫异常，但只有9名有症状，这表明表面健康的妇女可能将HTLV-III/LAV感染传染给她们的后代。
This study was done to gain insight into the clinical spectrum and immunologic disturbances resulting from infection with the human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) in children. Serum antibody to p41 antigen of HTLV-III and/or direct evidence of HTLV-III in lymphocytes was considered indicative of HTLV-III/LAV infection. In 36 children with HTLV-III/LAV infection, a wide clinical spectrum was noted, ranging from asymptomatic (seven children) to symptomatic, the latter including 14 children with the acquired immunodeficiency syndrome. Microcephaly was noted in five symptomatic infants. Immunologic dysfunction was noted in all symptomatic and in two asymptomatic children. Panhypogammaglobulinemia was noted in one child. Two asymptomatic children who were HTLV-III antibody negative had virologic evidence of HTLV-III infection. All of 20 mothers who were studied were HTLV-III antibody positive and had immunologic abnormalities but only nine were symptomatic, indicating that apparently healthy women may transmit HTLV-III/LAV infection to their offspring.
登录
查看更多内容
影响因子：
56.9
作者：
GONDA, MA;WONGSTAAL, F;GILDEN, RV
通讯作者：
GILDEN, RV
患有艾滋病相关综合症的人和有艾滋病风险的健康男同性恋者唾液中的 HTLV-III。
DOI：
10.1126/science.6093247
发表时间：
1984
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Groopman,JE;Salahuddin,SZ;Sarngadharan,MG;Markham,PD;Gonda,M;Sliski,A;Gallo,RC
通讯作者：
Gallo,RC
输血相关艾滋病病例的病毒学研究。
DOI：
10.1056/nejm198411293112206
发表时间：
1984
期刊：
The New England journal of medicine
影响因子：
--
作者：
Groopman,JE;Salahuddin,SZ;Sarngadharan,MG;Mullins,JI;Sullivan,JL;Mulder,C;O'Hara,CJ;Cheeseman,SH;Haverkos,H;Forgacs,P
通讯作者：
Forgacs,P
婴儿获得性免疫缺陷综合症。
DOI：
10.1001/archpedi.1983.02140350003001
发表时间：
1983
期刊：
American journal of diseases of children (1960)
影响因子：
--
作者：
Rubinstein,A
通讯作者：
Rubinstein,A
获得性免疫缺陷综合征的母婴传播。
影响因子：
8
作者：
Cowan,MJ;Hellmann,D;Chudwin,D;Wara,DW;Chang,RS;Ammann,AJ
通讯作者：
Ammann,AJ