Vasculocentric Axonal NfH in Small Vessel Disease.
Vasculocentric Axonal NfH in Small Vessel Disease.
复制标题
小血管疾病中的血管中心轴突NFH。
DOI：
10.1093/jnen/nlab134
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发表时间：
2022-02-24
影响因子：
3.2
通讯作者：
Hainsworth AH
中科院分区：
文献类型：
--
作者：
Anad A;Barker MK;Katanga JA;Arfanakis K;Bridges LR;Esiri MM;Isaacs JD;Prpar Mihevc S;Pereira AC;Schneider JA;Hainsworth AH
脑小血管病（SVD）导致老年人腔隙性卒中和血管性认知障碍。SVD中从血管病理到实质损伤的致病途径尚不清楚。神经丝是轴突结构蛋白。神经毒性光（NfL）是神经系统疾病的新兴生物标志物。在这里，我们研究了高分子量形式的神经毒性重（NfH）和量化的动脉周围（血管中心）NfH标记的特征模式。来自年轻人对照组、老年人对照组和患有SVD或严重阿尔茨海默病的老年人（n = 52）的皮质下额叶和顶叶白色物质被化学标记为过度磷酸化NfH（pNfH）。定量pNfH免疫标记的程度和血管中心性轴突pNfH的程度。轴突pNfH免疫标记在年轻人中是稀疏的，但在老年人中是常见的发现（对照、SVD或AD）。轴突pNfH通常明显集中在小穿通动脉周围。这种血管中心性特征在老年SVD患者中比在重度AD患者中更常见（p = 0.004）。我们的结论是，轴突pNfH是一个功能的皮质下白色物质在老年人的大脑。血管中心性轴突pNfH是一种新的实质病变，与SVD动脉病共存，可能是血管病理学的结果。
Cerebral small vessel disease (SVD) causes lacunar stroke and vascular cognitive impairment in older people. The pathogenic pathways from vessel pathology to parenchymal damage in SVD are unknown. Neurofilaments are axonal structural proteins. Neurofilament-light (NfL) is an emerging biomarker for neurological disease. Here, we examined the high molecular weight form neurofilament-heavy (NfH) and quantified a characteristic pattern of peri-arterial (vasculocentric) NfH labeling. Subcortical frontal and parietal white matter from young adult controls, aged controls, and older people with SVD or severe Alzheimer disease (n = 52) was immunohistochemically labeled for hyperphosphorylated NfH (pNfH). The extent of pNfH immunolabeling and the degree of vasculocentric axonal pNfH were quantified. Axonal pNfH immunolabeling was sparse in young adults but a common finding in older persons (controls, SVD, or AD). Axonal pNfH was often markedly concentrated around small penetrating arteries. This vasculocentric feature was more common in older people with SVD than in those with severe AD (p = 0.004). We conclude that axonal pNfH is a feature of subcortical white matter in aged brains. Vasculocentric axonal pNfH is a novel parenchymal lesion that is co-located with SVD arteriopathy and could be a consequence of vessel pathology.
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DOI：
10.1083/jcb.200303138
发表时间：
2003-05-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ackerley S;Thornhill P;Grierson AJ;Brownlees J;Anderton BH;Leigh PN;Shaw CE;Miller CC
通讯作者：
Miller CC
影响因子：
4.7
作者：
Veeranna;Lee JH;Pareek TK;Jaffee H;Boland B;Vinod KY;Amin N;Kulkarni AB;Pant HC;Nixon RA
通讯作者：
Nixon RA
影响因子：
2.5
作者：
LAWSON, SN;HARPER, AA;ANDERTON, BH
通讯作者：
ANDERTON, BH
影响因子：
11
作者：
Esiri, MM;Wilcock, GK;Morris, JH
通讯作者：
Morris, JH
影响因子：
8.2
作者：
Duering, Marco;Konieczny, Marek J.;Peters, Nils
通讯作者：
Peters, Nils