Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.
Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.
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DOI：
10.1186/ar2316
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发表时间：
2007
影响因子：
4.9
通讯作者：
Martínez-Lavín M
中科院分区：
文献类型：
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作者：
Vargas-Alarcón G;Fragoso JM;Cruz-Robles D;Vargas A;Vargas A;Lao-Villadóniga JI;García-Fructuoso F;Ramos-Kuri M;Hernández F;Springall R;Bojalil R;Vallejo M;Martínez-Lavín M
植物神经功能障碍是常见的纤维肌痛（FM）患者。心率变异性分析显示了持续的交感神经过度活跃的迹象。儿茶酚胺是交感神经递质。儿茶酚-O-甲基转移酶（COMT）是一种酶，是清除儿茶酚胺的主要途径。在COMT基因中有几个单核苷酸多态性（SNP）与COMT酶的不同儿茶酚胺清除能力相关。这些SNPs处于连锁不平衡中，并作为“单倍型”分离。具有特定COMT基因单倍型（ACCG）的健康女性对疼痛刺激更敏感。我们研究的目的是确定来自两个不同国家（墨西哥和西班牙）的FM女性是否具有COMT基因单倍型，这些单倍型以前与对疼痛更敏感有关。研究中的所有个体都是女性。将57名墨西哥患者和78名西班牙患者与各自的健康对照组进行了比较。所有参与者都填写了纤维肌痛影响问卷（FIQ）。从外周血DNA中对6个COMT SNP（rs 2097903、rs6269、rs 4633、rs 4818、rs 4680和rs 165599）进行基因分型。在西班牙患者中，与健康对照相比，三种SNP（rs6269、rs 4818和rs 4680）与FM的存在存在显着相关。此外，在西班牙患者的“高疼痛敏感性”单倍型（ACCG），疾病，由FIQ评估，更严重。相比之下，墨西哥患者仅显示rs6269和rs 165599以及一些FIQ子量表之间的弱关联。在我们的西班牙患者组中，FM和先前与高疼痛敏感性相关的COMT单倍型之间存在关联。在墨西哥患者中未观察到这种关联。为了验证或修正这些初步结果，需要进行更大样本量的研究。
Autonomic dysfunction is frequent in patients with fibromyalgia (FM). Heart rate variability analyses have demonstrated signs of ongoing sympathetic hyperactivity. Catecholamines are sympathetic neurotransmitters. Catechol-O-methyltransferase (COMT), an enzyme, is the major catecholamine-clearing pathway. There are several single-nucleotide polymorphisms (SNPs) in the COMT gene associated with the different catecholamine-clearing abilities of the COMT enzyme. These SNPs are in linkage disequilibrium and segregate as 'haplotypes'. Healthy females with a particular COMT gene haplotype (ACCG) producing a defective enzyme are more sensitive to painful stimuli. The objective of our study was to define whether women with FM, from two different countries (Mexico and Spain), have the COMT gene haplotypes that have been previously associated with greater sensitivity to pain. All the individuals in the study were female. Fifty-seven Mexican patients and 78 Spanish patients were compared with their respective healthy control groups. All participants filled out the Fibromyalgia Impact Questionnaire (FIQ). Six COMT SNPs (rs2097903, rs6269, rs4633, rs4818, rs4680, and rs165599) were genotyped from peripheral blood DNA. In Spanish patients, there was a significant association between three SNPs (rs6269, rs4818, and rs4680) and the presence of FM when compared with healthy controls. Moreover, in Spanish patients with the 'high pain sensitivity' haplotype (ACCG), the disease, as assessed by the FIQ, was more severe. By contrast, Mexican patients displayed only a weak association between rs6269 and rs165599, and some FIQ subscales. In our group of Spanish patients, there was an association between FM and the COMT haplotype previously associated with high pain sensitivity. This association was not observed in Mexican patients. Studies with a larger sample size are needed in order to verify or amend these preliminary results.
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影响因子：
3.5
作者：
Diatchenko, L;Slade, GD;Maixner, W
通讯作者：
Maixner, W
DOI：
10.1007/s10194-006-0281-7
发表时间：
2006-04-01
期刊：
The journal of headache and pain
影响因子：
--
作者：
Hagen, Knut;Pettersen, Elin;Zwart, John-Anker
通讯作者：
Zwart, John-Anker
影响因子：
27.4
作者：
Carmona, L;Ballina, J;Laffon, A
通讯作者：
Laffon, A
影响因子：
3.6
作者：
Vargas-Alarcon, Gilberto;Moscoso, Juan;Arnaiz-Villena, Antonio
通讯作者：
Arnaiz-Villena, Antonio
影响因子：
--
作者：
Arnold, LM;Hudson, JI;Keck, PE
通讯作者：
Keck, PE