Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes.
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes.
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DOI：
10.1586/eri.12.50
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发表时间：
2012-06
影响因子：
5.7
通讯作者：
Martin GS
中科院分区：
文献类型：
--
作者：
Martin GS
脓毒症自远古时代就已存在，虽其临床定义是近期才有的，但它已被描述了2000多年。脓毒症的共识性定义使得全球范围内的脓毒症流行病学研究得以开展。我们现在认识到脓毒症的常见性及其疾病的一致性——尤其是严重脓毒症和感染性休克。脓毒症、严重脓毒症和感染性休克的发病率持续上升，尽管革兰阳性菌病原体仍然是脓毒症最常见的病因，但真菌类病原体正在迅速增加。在过去的半个世纪里，我们在识别和治疗脓毒症患者方面取得了进展，死亡率的下降反映了这一进展。然而，由于脓毒症发病率的上升，每年死亡的人数仍在持续增加。脓毒症的死亡率，尤其是与器官功能障碍治疗相关的死亡率，仍然是全球临床医生关注的重点，也值得公共卫生领域给予更多关注。
Sepsis has been around since the dawn of time, having been described for more than 2000 years, although clinical definitions are recent. The consensus sepsis definitions have permitted worldwide epidemiological studies of sepsis to be conducted. We now recognize the common nature of sepsis and the consistency of its disease – particularly severe sepsis and septic shock. The incidence of sepsis, severe sepsis and septic shock continues to increase, and although Gram-positive bacterial pathogens remain the most common cause of sepsis, fungal organisms are increasing rapidly. We have made progress over the past half-century in identifying and treating patients with sepsis, and decreasing fatality rates reflect this progress. However, owing to the increasing incidence of sepsis, the number of people who die each year continues to increase. The mortality with sepsis, particularly related to treating organ dysfunction, remains a priority to clinicians worldwide and is deserving of greater public health attention.
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