Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia: A systematic review and meta-analysis.
Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia: A systematic review and meta-analysis.
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DOI：
10.1016/j.mad.2020.111386
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发表时间：
2020-12
影响因子：
5.3
通讯作者：
Geerlings MI
中科院分区：
文献类型：
--
作者：
Vonk JMJ;Twait EL;Scholten RJPM;Geerlings MI
先前的研究表明，在阿尔茨海默病的早期阶段存在细微的语义衰退。本研究调查了淀粉样蛋白负担（阿尔茨海默病的生物标志物）与无痴呆老年人语义损伤任务之间的关系。在MEDLINE， PsycINFO和Embase中进行系统搜索，得出3691篇同行评审的文章，不包括重复的文章。筛选后，41项研究共7495名参与者被纳入meta分析和质量评估。较大的淀粉样蛋白负担与较大的语义损伤之间的总体加权效应大小在图片命名方面为0.10 (95% CI [- 0.03; 0.22], p = 0.128)，在语义流畅性方面为0.19 (95% CI [0.11; 0.27], p < 0.001)，在词汇方面为0.15 (95% CI [- 0.15; 0.45], p = 0.326)，在WAIS信息方面为0.10 （95% CI [- 0.14; 0.35], p = 0.405； 2项研究）。可比性方面的偏倚风险最高，因为效应大小通常不是通过协变量调整统计来计算的。淀粉样蛋白相关的语义流畅性下降与研究和临床应用的相关性可能可以忽略不计，因为影响的幅度很小。未来的研究应该开发更敏感的语义流畅度指标，以优化其在阿尔茨海默病相关认知障碍的早期检测中的应用。
Previous research suggests the presence of subtle semantic decline in early stages of Alzheimer’s disease. This study investigated associations between amyloid burden, a biomarker for Alzheimer’s disease, and tasks of semantic impairment in older individuals without dementia. A systematic search in MEDLINE, PsycINFO, and Embase yielded 3691 peer-reviewed articles excluding duplicates. After screening, 41 studies with overall 7495 participants were included in the meta-analysis and quality assessment. The overall weighted effect size of the association between larger amyloid burden and larger semantic impairment was 0.10 (95% CI [−0.03; 0.22], p = 0.128) for picture naming, 0.19 (95% CI [0.11; 0.27], p < 0.001) for semantic fluency, 0.15 (95% CI [−0.15; 0.45], p = 0.326) for vocabulary, and 0.10 (95% CI [−0.14; 0.35], p = 0.405; 2 studies) for WAIS Information. Risk of bias was highest regarding comparability, as effect sizes were often not calculated on covariate-adjusted statistics. The relevance of the indicated amyloid-related decline in semantic fluency for research and clinical applications is likely negligible due to the effect’s small magnitude. Future research should develop more sensitive metrics of semantic fluency to optimize its use for early detection of Alzheimer’s disease-related cognitive impairment.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
2.6
作者：
Amariglio RE;Becker JA;Carmasin J;Wadsworth LP;Lorius N;Sullivan C;Maye JE;Gidicsin C;Pepin LC;Sperling RA;Johnson KA;Rentz DM
通讯作者：
Rentz DM
影响因子：
4
作者：
Didic, Mira;Barbeau, Emmanuel J.;Ceccaldi, Mathieu
通讯作者：
Ceccaldi, Mathieu
影响因子：
3.6
作者：
Capitani, E;Laiacona, M;Barbarotto, R
通讯作者：
Barbarotto, R
DOI：
10.1016/j.dadm.2016.09.002
发表时间：
2017
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Baker JE;Lim YY;Pietrzak RH;Hassenstab J;Snyder PJ;Masters CL;Maruff P
通讯作者：
Maruff P