Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience.
Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience.
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DOI：
10.1016/j.dcn.2013.10.003
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发表时间：
2014-04
影响因子：
4.7
通讯作者：
Guyer, Amanda E.
中科院分区：
文献类型：
--
作者：
Caouette, Justin D.;Guyer, Amanda E.
青春期会增加社交焦虑障碍（SAD）发病的风险。早期生活中的行为抑制气质是SAD的风险之一。SAD的脆弱性反映了社会和非社会奖励的高度突出性。回避相关系统（即杏仁核）和接近动机系统（即纹状体）与青少年SAD和行为抑制有关。社交焦虑障碍（SAD）明显损害日常功能。对于青少年来说，正是在社会经验拓宽、同伴意见高度突出、积极寻求社会认可的时候，SAD才会制约典型发展。具有极端、损害性社交焦虑的个体害怕他人的评价，避免社交互动，并将模糊的社交暗示解释为威胁。然而，某种程度的社交焦虑可能是正常的、无害的。此外，行为抑制的气质增加了某些人患SAD的风险，但并非所有具有这种气质的青少年。为了理解社交焦虑的机制，一种卓有成效的方法是利用神经成像将情感和认知与涉及青少年神经发育社会重新定位的神经网络联系起来。尽管最初的关于青少年SAD和SAD风险的神经影像学研究强调了恐惧处理回路（例如，杏仁核和腹侧前额叶皮层）的作用，但最近的工作已经将这些回路扩展到包括基底神经节中的奖励处理结构。越来越多的人关注奖励相关的神经回路，这为创新的转化研究带来了希望，这些研究需要将损害与规范的社交焦虑区分开来，并为治疗青少年SAD的新方法提供了希望，这些新方法既关注社交回避，也关注社交途径。
Adolescence brings heightened risk for social anxiety disorder (SAD) onset. Early-life temperament of behavioral inhibition is a documented risk for SAD. Vulnerability to SAD reflects heightened salience of social and non-social rewards. Avoidance-related (i.e., amygdala) and approach-motivational (i.e., striatum) systems are associated with adolescent SAD and behavioral inhibition. Social anxiety disorder (SAD) markedly impairs daily functioning. For adolescents, SAD can constrain typical development precisely when social experiences broaden, peers’ opinions are highly salient, and social approval is actively sought. Individuals with extreme, impairing social anxiety fear evaluation from others, avoid social interactions, and interpret ambiguous social cues as threatening. Yet some degree of social anxiety can be normative and non-impairing. Furthermore, a temperament of behavioral inhibition increases risk for SAD for some, but not all adolescents with this temperament. One fruitful approach taken to understand the mechanisms of social anxiety has been to use neuroimaging to link affect and cognition with neural networks implicated in the neurodevelopmental social reorientation of adolescence. Although initial neuroimaging studies of adolescent SAD and risk for SAD underscored the role of fear-processing circuits (e.g., the amygdala and ventral prefrontal cortex), recent work has expanded these circuits to include reward-processing structures in the basal ganglia. A growing focus on reward-related neural circuitry holds promise for innovative translational research needed to differentiate impairing from normative social anxiety and for novel ways to treat adolescent SAD that focus on both social avoidance and social approach.
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影响因子：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
DOI：
10.1097/chi.0b013e3181ae09df
发表时间：
2009-09
影响因子：
13.3
作者：
Chronis-Tuscano A;Degnan KA;Pine DS;Perez-Edgar K;Henderson HA;Diaz Y;Raggi VL;Fox NA
通讯作者：
Fox NA
影响因子：
4.6
作者：
Calkins, SD;Fox, NA;Marshall, TR
通讯作者：
Marshall, TR
影响因子：
5.3
作者：
Bjork, JM;Knutson, B;Hommer, DW
通讯作者：
Hommer, DW
影响因子：
3.6
作者：
BEIDEL, DC;CHRIST, MAG;LONG, PJ
通讯作者：
LONG, PJ