Common and distinct amygdala-function perturbations in depressed vs anxious adolescents.
Common and distinct amygdala-function perturbations in depressed vs anxious adolescents.
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DOI：
10.1001/archgenpsychiatry.2008.545
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发表时间：
2009-03
影响因子：
--
通讯作者：
Pine, Daniel S.
中科院分区：
文献类型：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
很少有研究直接比较抑郁症和焦虑症患者的杏仁核功能。来自纵向研究的数据强调了在青少年中进行此类研究的必要性。比较患有严重抑郁障碍(MDD)或焦虑症的青少年与没有精神病理改变的青少年对不同注意力和情绪状况的杏仁核反应。病例对照研究。政府临床研究所。87名青少年在年龄、性别、智力和社会阶层上匹配：26名患有MDD(14名患有焦虑症，12名没有焦虑症)，16名有焦虑症但没有抑郁，45名没有精神病理。杏仁核血氧水平依赖信号，通过事件相关功能磁共振成像测量。在成像过程中，参与者观察面部表情(中性、恐惧、愤怒和高兴)，而注意力受到限制(恐惧、敌意和鼻子宽评级)或不受限制(被动观看)。左右杏仁核的激活随着诊断、面部表情和注意状况的不同而不同，无论是在包括患有精神障碍和焦虑的患者时，还是在排除他们时都是如此(组×情绪×注意互动，P≤.03)。关注可怕的看脸事件，焦虑症患者和MDD患者在健康参与者的杏仁核反应上都有所不同，而且在被动观看时彼此也不同。然而，与健康参与者相比，MDD组和焦虑组在主观经历恐惧的情况下，表现出与恐惧面孔相似的杏仁核过度激活迹象。青春期MDD和焦虑症在面孔加工过程中表现出共同和不同的功能神经关联。相对于健康的同龄人，注意力调节了这些患者组中常见的或不同的杏仁核干扰的程度。
Few studies directly compare amygdala function in depressive and anxiety disorders. Data from longitudinal research emphasize the need for such studies in adolescents. To compare amygdala response to varying attention and emotion conditions among adolescents with major depressive disorder (MDD) or anxiety disorders, relative to adolescents with no psychopathology. Case-control study. Government clinical research institute. Eighty-seven adolescents matched on age, sex, intelligence, and social class: 26 with MDD (14 with and 12 without anxiety disorders), 16 with anxiety disorders but no depression, and 45 without psychopathology. Blood oxygen level–dependent signal in the amygdala, measured by means of event-related functional magnetic resonance imaging. During imaging, participants viewed facial expressions (neutral, fearful, angry, and happy) while attention was constrained (afraid, hostility, and nose-width ratings) or unconstrained (passive viewing). Left and right amygdala activation differed as a function of diagnosis, facial expression, and attention condition both when patients with comorbid MDD and anxiety were included and when they were excluded (group × emotion × attention interactions, P≤.03). Focusing on fearful face–viewing events, patients with anxiety and those with MDD both differed in amygdala responses from healthy participants and from each other during passive viewing. However, both MDD and anxiety groups, relative to healthy participants, exhibited similar signs of amygdala hyperactivation to fearful faces when subjectively experienced fear was rated. Adolescent MDD and anxiety disorders exhibit common and distinct functional neural correlates during face processing. Attention modulates the degree to which common or distinct amygdala perturbations manifest in these patient groups, relative to healthy peers.
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影响因子：
--
作者：
Beesdo, Katja;Bittner, Antje;Wittchen, Hans-Ulrich
通讯作者：
Wittchen, Hans-Ulrich
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
10.5
作者：
Goldberg, D
通讯作者：
Goldberg, D
影响因子：
10.6
作者：
McClure, EB;Monk, CS;Pine, DS
通讯作者：
Pine, DS
影响因子：
4.6
作者：
Krueger, RF;Caspi, A;Silva, PA
通讯作者：
Silva, PA