Negative prognostic impact of low absolute CD4(+) T cell counts in peripheral blood in mantle cell lymphoma.
Negative prognostic impact of low absolute CD4(+) T cell counts in peripheral blood in mantle cell lymphoma.
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套细胞淋巴瘤外周血 CD4( ) T 细胞绝对计数低的负面预后影响
DOI：
10.1111/cas.13020
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发表时间：
2016-10
期刊：
影响因子：
5.7
通讯作者：
Xu W
中科院分区：
文献类型：
--
作者：
Zhang XY;Xu J;Zhu HY;Wang Y;Wang L;Fan L;Wu YJ;Li JY;Xu W
套细胞淋巴瘤(MCL)患者的预后与肿瘤微环境和宿主免疫密切相关。然而，很少有研究人员关注外周血淋巴细胞亚群计数的预后价值。本研究的目的是探讨淋巴细胞亚群和单核细胞绝对数对预后的预测价值。对68例患者进行了回顾性分析。采用外周血流式细胞仪检测患者外周血中CD4+T细胞绝对计数(ACD4C)、CD8+T细胞计数、自然杀伤细胞计数和CD4/CD8比值，并与临床参数和远期疗效进行相关性分析。所有患者的中位随访时间为21个月，中位生存期为44个月。1、3、5年总生存率分别为80%、51%、41%。单因素分析显示，单核细胞绝对值高、ACD_4C和CD_4/CD_8比值低与OS不良相关(分别为P=0.029、P=0.027和P=0.045)。多因素分析显示，在接受或不接受利妥昔单抗治疗的患者中，低ACD4C是OS不良的显著预测因素(P=0.004)，独立于简化的MCL国际预后指数(P=0.048)(P=0.011)。低的CD4+T细胞计数被证明是MCL患者不良OS的重要预测因子。
Tumor microenvironment and host immunity are closely related to outcome in patients with mantle cell lymphoma (MCL). However, few researchers have focused on the prognostic value of peripheral blood lymphocyte subsets counts. The purpose of this study was to investigate the prognostic value of lymphocyte subsets and absolute monocyte counts. Sixty‐eight patients were analyzed retrospectively. Absolute CD4+ T cell counts (ACD4C), CD8+ T cell counts, nature killer cell counts, and CD4/CD8 ratios were assessed by peripheral blood flow cytometry and correlated with clinical parameters and long‐term outcomes. The median follow‐up for all patients was 21 months and the median survival time was 44 months. The overall survival (OS) rate at 1, 3, and 5 years was 80%, 51%, and 41%, respectively. In our cohort, high absolute monocyte count, and low ACD4C and CD4/CD8 ratio were associated with unfavorable OS (P = 0.029, P = 0.027, and P = 0.045, respectively) by univariate analysis. Multivariate analysis indicated that low ACD4C was a significant predictor of unfavorable OS (P = 0.004) independent of the simplified MCL International Prognostic Index (P = 0.048) in patients treated with or without rituximab (P = 0.011). Low CD4+ T cell counts proved to be a significant predictor of unfavorable OS in patients with MCL.
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影响因子：
10.1
作者：
Wang, Lijuan;Qian, Jianfei;Cai, Zhen
通讯作者：
Cai, Zhen
影响因子：
11.5
作者：
Nygren, Lina;Wasik, Agata M.;Sander, Birgitta
通讯作者：
Sander, Birgitta
影响因子：
12.8
作者：
Rambaldi, Alessandro;Boschini, Cristina;Tarella, Corrado
通讯作者：
Tarella, Corrado
影响因子：
2.7
作者：
Belotti, Angelo;Doni, Elisa;Pioltelli, Pietro Enrico
通讯作者：
Pioltelli, Pietro Enrico
影响因子：
50.3
作者：
Rakhra K;Bachireddy P;Zabuawala T;Zeiser R;Xu L;Kopelman A;Fan AC;Yang Q;Braunstein L;Crosby E;Ryeom S;Felsher DW
通讯作者：
Felsher DW