Inflammation and immunity in radiation damage to the gut mucosa.
Inflammation and immunity in radiation damage to the gut mucosa.
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DOI：
10.1155/2013/123241
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发表时间：
2013
影响因子：
--
通讯作者：
Benderitter M
中科院分区：
文献类型：
--
作者：
François A;Milliat F;Guipaud O;Benderitter M
在接受放射治疗的第一批患者的皮肤上观察到红斑。特别是为了减少这种红斑，组织炎症的一个特征，开始对肿瘤部位的处方剂量进行分级。现在众所周知，正常组织的辐射暴露产生持续的和明显不受控制的炎症过程。辐射引起的炎症总是被观察到，经常被描述，有时被部分解释，但今天仍然远未被完全理解。肠道，尤其是肠道粘膜，处于外部环境和机体之间的边界，与过多的自体抗原和外来抗原接触，具有密集相关的淋巴组织，并且由于粘膜更新率高，对辐射特别敏感。所有这些特性使得肠粘膜在辐射诱导的免疫炎症方面成为强反应性器官。本文将重点介绍在正常肠道中观察到的情况，以及在局部辐射暴露后免疫炎症反应方面还有待研究的问题。
Erythema was observed on the skin of the first patients treated with radiation therapy. It is in particular to reduce this erythema, one feature of tissue inflammation, that prescribed dose to the tumor site started to be fractionated. It is now well known that radiation exposure of normal tissues generates a sustained and apparently uncontrolled inflammatory process. Radiation-induced inflammation is always observed, often described, sometimes partly explained, but still today far from being completely understood. The thing with the gut and especially the gut mucosa is that it is at the frontier between the external milieu and the organism, is in contact with a plethora of commensal and foreign antigens, possesses a dense-associated lymphoid tissue, and is particularly radiation sensitive because of a high mucosal turnover rate. All these characteristics make the gut mucosa a strong responsive organ in terms of radiation-induced immunoinflammation. This paper will focus on what has been observed in the normal gut and what remains to be done concerning the immunoinflammatory response following localized radiation exposure.
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影响因子：
2.6
作者：
François, A;Milliat, F;Griffiths, NM
通讯作者：
Griffiths, NM
影响因子：
2.6
作者：
François, A;Aigueperse, J;Griffiths, NM
通讯作者：
Griffiths, NM
影响因子：
4.3
作者：
Gremy, Olivier;Benderitter, Marc;Linard, Christine
通讯作者：
Linard, Christine
DOI：
10.1016/s0360-3016(00)00744-6
发表时间：
2000-11-01
影响因子：
7
作者：
Hovdenak, N;Fajardo, LF;Hauer-Jensen, M
通讯作者：
Hauer-Jensen, M
影响因子：
5.7
作者：
LANGBERG, CW;HAUERJENSEN, M;KANE, CJM
通讯作者：
KANE, CJM