The Specificity of Paranoia and Uncertainty.

The Specificity of Paranoia and Uncertainty.
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DOI:
10.1016/j.bpsc.2022.09.011
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发表时间:
2022-11
期刊:
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子:
--
通讯作者:
--
中科院分区:
其他
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偏执狂与严重的痛苦和照顾自己的额外挑战有关,例如社会孤立,自杀倾向和治疗依从性差。对于经历偏执狂的人来说,被定义为相信其他人故意试图伤害个人,症状可以从与同龄人的有限社交互动到对亲人或陌生人进行口头或身体抨击。先前的研究表明,偏执狂是一个连续体(1)。在研究偏执狂的临床水平时,大部分文献都集中在诊断组,如精神分裂症谱系障碍。然而,对于包括精神病在内的疾病,这可能是相当异质性的,关注有问题的症状可能会提供更有针对性的治疗。人们对偏执狂越来越感兴趣,偏执狂是造成大约70%妄想的原因,因此可以提供最大的杠杆来解决这些妄想来自哪里以及它们是如何维持的。偏执狂与担忧有重叠的成分,例如对不愉快想法的固定和对不可能结果的担忧。重要的是,以前的研究表明,迫害性担忧和一般性担忧是相关的,但可以分开(2)。此外,将偏执狂与其他妄想内容(夸大、躯体、色情狂等)分开也很重要。这可能开始回答妄想是如何产生的:是不是每个经历妄想的人都容易受到夸大生活中问题的认知扭曲的影响?还是错觉是通过多种方式产生的?
Paranoia is associated with significant suffering and additional challenges in caring for oneself, such as social isolation, suicidality, and poor treatment compliance. For individuals experiencing paranoia, defined as a belief that others are intentionally trying to harm the individual, the symptoms can range from limited social interaction with peers to verbally or physically lashing out at loved ones or strangers. Previous work has suggested that paranoia lies on a continuum (1). When examining clinical levels of paranoia, much of the literature focuses on diagnostic groups, such as schizophrenia spectrum disorders. Yet for disorders that include psychosis, which can be quite heterogeneous, a focus on problematic symptoms may offer more targeted treatment. There has been increasing interest in paranoia, which is responsible for approximately 70% of delusions and therefore may provide the most leverage to address where these delusions come from and how they are maintained.An important aspect of symptom-specific assessment is distinguishing symptoms from one another. Paranoia has overlapping components with worry, such as fixation on unpleasant thoughts and concern about unlikely outcomes. Importantly, previous work has shown that persecutory worry and general worry are related, but separable (2). In addition, it is important to separate paranoia from other delusional content (grandiosity, somatic, erotomania, etc.). This may begin to answer how delusions arise: Is everyone who experiences a delusion simply susceptible to cognitive distortions that exaggerate issues in their lives? Or do delusions arise through multiple methods?
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