Evolution of Digestive Enzymes and RNASE1 Provides Insights into Dietary Switch of Cetaceans.
Evolution of Digestive Enzymes and RNASE1 Provides Insights into Dietary Switch of Cetaceans.
复制标题
消化酶和 RNASE1 的进化为鲸类动物的饮食转换提供了见解
DOI：
10.1093/molbev/msw191
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发表时间：
2016-12
影响因子：
10.7
通讯作者：
Yang G
中科院分区：
文献类型：
--
作者：
Wang Z;Xu S;Du K;Huang F;Chen Z;Zhou K;Ren W;Yang G
虽然鲸类动物（鲸鱼，鼠海豚和海豚）有多腔胃，但现代鲸类动物的饮食习惯已经从草食性转变为肉食性。然而，这种饮食转变背后的遗传基础仍然未被探索。在这里，我们提出了10个消化酶基因（即，CYP7A1、CTRC、LIPC、LIPF、PNLIP、PGC、PRSS1、SI、SLC5A1和TMPRSS15），以及RNASE1在偶蹄类动物中的进化轨迹。用蛋白酶检测阳性选择（即，CTRC、PRSS 1和TMPRSS 15）和脂肪酶（即，CYP7A1、LIPF和PNLIP），表明鲸类已经进化出增强的蛋白质和脂质消化能力，这是其猎物（鱼类和无脊椎动物）的主要营养成分。此外，研究还发现RNASE1基因在偶蹄类物种形成后发生了复制，在骆驼科和反刍动物中发生了两次独立的基因复制事件。骆驼科和牛科的RNASE1检测到阳性选择，表明反刍动物的消化效率提高。值得注意的是，尽管鲸类动物的祖先是食草的陆生偶蹄类动物，但现代鲸类动物失去了具有消化功能的胰腺RNASE1拷贝，这与从食草到食肉的饮食变化是一致的。总之，这是第一项为鲸类动物饮食转换的进化机制提供新见解的研究。
Although cetaceans (whales, porpoises, and dolphins) have multi-chambered stomachs, feeding habits of modern cetaceans have dramatically changed from herbivorous to carnivorous. However, the genetic basis underlying this dietary switch remains unexplored. Here, we present the first systematic investigation of 10 digestive enzymes genes (i.e., CYP7A1, CTRC, LIPC, LIPF, PNLIP, PGC, PRSS1, SI, SLC5A1, and TMPRSS15) of representative cetaceans, and the evolutionary trajectory of RNASE1 in cetartiodactylans. Positive selections were detected with proteinases (i.e., CTRC, PRSS1, and TMPRSS15) and lipases (i.e., CYP7A1, LIPF, and PNLIP) suggesting that cetaceans have evolved an enhanced digestion capacity for proteins and lipids, the major nutritional components of their prey (fishes and invertebrates). In addition, it was found that RNASE1 gene duplicated after the cetartiodactylan speciation and two independent gene duplication events took place in Camelidae and Ruminantia. Positive selection was detected with RNASE1 of Camelidae and Bovidae, suggesting enhanced digestive efficiency in the ruminants. Remarkably, even though the ancestors of cetaceans were terrestrial artiodactyls that are herbivorous, modern cetaceans lost the pancreatic RNASE1 copy with digestive function, which is in accordance with the dietary change from herbivorous to carnivorous. In sum, this is the first study that provides new insights into the evolutionary mechanism of dietary switch in cetaceans.
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影响因子：
4.5
作者：
Infante, J. L. Zambonino;Cahu, C. L.
通讯作者：
Cahu, C. L.
DOI：
10.1051/rnd:19800713
发表时间：
1980-01-01
期刊：
REPRODUCTION NUTRITION DEVELOPMENT
影响因子：
--
作者：
CORRING, T
通讯作者：
CORRING, T
DOI：
10.1016/j.cbpb.2008.01.007
发表时间：
2008-05-01
影响因子：
2.2
作者：
de Caro, Josiane;Eydoux, Cecilia;De Caro, Alain
通讯作者：
De Caro, Alain
影响因子：
4.8
作者：
Nemeth, Balazs Csaba;Wartmann, Thomas;Sahin-Toth, Miklos
通讯作者：
Sahin-Toth, Miklos
影响因子：
64.8
作者：
Axelsson, Erik;Ratnakumar, Abhirami;Lindblad-Toh, Kerstin
通讯作者：
Lindblad-Toh, Kerstin