Delta-Frequency Augmentation and Synchronization in Seizure Discharges and Telencephalic Transmission.
Delta-Frequency Augmentation and Synchronization in Seizure Discharges and Telencephalic Transmission.
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DOI：
10.1016/j.isci.2020.101666
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发表时间：
2020-11-20
期刊：
影响因子：
5.8
通讯作者：
Kuo CC
中科院分区：
文献类型：
--
作者：
Chou P;Wang GH;Hsueh SW;Yang YC;Kuo CC
癫痫发作是一种常见的神经系统疾病，主要通过大脑皮质局部场电位（LFP）或脑电图中的特征性节律或波来诊断。利用基底外侧杏仁核（BLA）点燃模型，我们发现在正常和癫痫发作状态下，BLA振荡的主频率都在δ范围内（1-5 Hz）。多单位放电随着癫痫发作分期的升高而增加，但在LFP中仍锁相至δ波。此外，同步性的变化先于放电单位的变化和行为癫痫发作，并且持续时间超过放电单位的变化。一个短串的刺激很容易驱动BLA切片中的神经元抑制神经元网络进入延长的混响活动，其中爆发和爆发间间隔可以同时为δ频率设置“自然波长”。因此，癫痫发作可以被视为一个系统中正常振荡的错误时空连续体，该系统具有内在的同步和共振性质，用于信息中继。δ振荡构成基底外侧杏仁核的自然频率神经元爆发和爆发间的间隔设定了δ振荡的波长δ振荡可以很容易地远距离传播并在行为上翻译同步先于并持续于发作发生中放电和癫痫发作的增加行为神经科学;系统神经科学;神经科学技术
Epileptic seizures constitute a common neurological disease primarily diagnosed by characteristic rhythms or waves in the local field potentials (LFPs) of cerebral cortices or electroencephalograms. With a basolateral amygdala (BLA) kindling model, we found that the dominant frequency of BLA oscillations is in the delta range (1–5 Hz) in both normal and seizure conditions. Multi-unit discharges are increased with higher seizure staging but remain phase-locked to the delta waves in LFPs. Also, the change in synchrony precedes and outlasts the changes in discharging units as well as behavioral seizures. One short train of stimuli readily drives the pyramidal-inhibitory neuronal networks in BLA slices into prolonged reverberating activities, where the burst and interburst intervals may concurrently set a “natural wavelength” for delta frequencies. Seizures thus could be viewed as erroneous temporospatial continuums to normal oscillations in a system with a built-in synchronizing and resonating nature for information relay. Delta oscillations constitute the natural frequencies in basolateral amygdala Neuronal burst and interburst intervals set the wavelength for delta oscillations Delta oscillations may be readily transmitted distantly and translated behaviorally Synchrony precedes and outlasts increase in discharges and seizures in ictogenesis Behavioral Neuroscience; Systems Neuroscience; Techniques in Neuroscience
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影响因子：
5.3
作者：
GODDARD, GV;MCINTYRE, DC;LEECH, CK
通讯作者：
LEECH, CK
影响因子：
1.7
作者：
Eggermont, JJ;Smith, GM
通讯作者：
Smith, GM
影响因子：
14.5
作者：
Hamer, HM;Lüders, HO;Rosenow, F
通讯作者：
Rosenow, F
影响因子：
5.6
作者：
Hamer, HM;Wyllie, E;Acharya, J
通讯作者：
Acharya, J
DOI：
10.1016/0013-4694(92)90116-y
发表时间：
1992-10-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
FAUGHT, E;KUZNIECKY, RI;HURST, DC
通讯作者：
HURST, DC