Involvement of CLEC16A in Activation of Astrocytes After LPS Treated
Involvement of CLEC16A in Activation of Astrocytes After LPS Treated
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LPS 处理后 CLEC16A 参与星形胶质细胞的激活
DOI：
10.1007/s11064-011-0581-4
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发表时间：
2011
影响因子：
4.4
通讯作者：
Kang, Lihua
中科院分区：
文献类型：
--
作者：
Gao, Yilu;Li, Jing;Chen, Chun;Yan, Yaohua;Jiang, Shengyang;Wu, Xiaohong;Shao, Bai;Xu, Jin;Kang, Lihua
CLEC16A是C型凝集素结构域家族16的成员，最近发现其与自身免疫性疾病的膨胀过程相关。本研究旨在阐明CLEC16 A在脂多糖（LPS）诱导的成年大鼠神经炎症过程中的动态表达变化及定位。CLEC16A的表达在发炎的大脑皮层中的活性星形胶质细胞中被强烈诱导。体外研究表明CLEC16A的上调可能参与了LPS刺激后星形胶质细胞的活化。用siRNA敲低原代培养的星形胶质细胞CLEC16A的表达，结果表明CLEC16A是LPS诱导星形胶质细胞活化所必需的。总的来说，这些结果表明CLEC16 A可能在星形胶质细胞介导的免疫应答中的宿主防御中是重要的。了解中枢神经系统的细胞信号通路，可能为中枢神经系统炎症反应和免疫反应的防治提供新的策略。
CLEC16A, C-type lectin domain family 16, member A was recently found to be associated with inflation process in the autoimmune diseases. In this study, we elucidated the dynamic expression changes and localization of CLEC16A in lipopolysaccharide (LPS)-induced neuroinflammatory processes in adult rats. CLEC16A expression was strongly induced in active astrocytes in inflamed cerebral cortex. In vitro studies indicated that the up-regulation of CLEC16A may be involved in the subsequent astrocyte activation following LPS challenge. And Knock-down of CLEC16A in cultured primary astrocytes by siRNA showed that CLEC16A was required for the activation of astrocytes induced by LPS. Collectively, these results suggested CLEC16A may be important in host defense in astrocyte-mediated immune response. Understanding the cell signal pathway may provide a novel strategy against inflammatory and immune reaction in neuroinflammtion in CNS.
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DOI：
10.1038/nri2569
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Geijtenbeek TB;Gringhuis SI
通讯作者：
Gringhuis SI
影响因子：
20.3
作者：
F. Salvi;D. Gioia;S. Gatto;M. Bonferroni;G. Cametti;E. Campa;C. Ceretto;D. Cilloni;Antonella Darbesio;S. D’ardia;C. Dellacasa;D. Ferrero;F. Ficara;S. Franceschetti;R. Freilone;F. Marmont;E. Scassa;A. Tonso;M. Boccadoro;G. Gaidano;A. Gallamini;E. Gallo;M. Girotto;C. Marinone;G. Saglio;A. Levis
通讯作者：
F. Salvi;D. Gioia;S. Gatto;M. Bonferroni;G. Cametti;E. Campa;C. Ceretto;D. Cilloni;Antonella Darbesio;S. D’ardia;C. Dellacasa;D. Ferrero;F. Ficara;S. Franceschetti;R. Freilone;F. Marmont;E. Scassa;A. Tonso;M. Boccadoro;G. Gaidano;A. Gallamini;E. Gallo;M. Girotto;C. Marinone;G. Saglio;A. Levis
影响因子：
6.2
作者：
GEHRMANN, J;BANATI, RB;NEWCOMBE, J
通讯作者：
NEWCOMBE, J
影响因子：
15.9
作者：
Kreutzberg, GW
通讯作者：
Kreutzberg, GW
DOI：
10.1124/jpet.102.035048
发表时间：
2003-01-01
影响因子：
3.5
作者：
Liu, B;Hong, JS
通讯作者：
Hong, JS