Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research.
Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research.
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全氟和多氟烷基物质毒性与人类健康回顾：知识现状和未来研究策略。
DOI：
10.1002/etc.4890
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发表时间：
2021-03
影响因子：
4.1
通讯作者：
Roberts SM
中科院分区：
文献类型：
--
作者：
Fenton SE;Ducatman A;Boobis A;DeWitt JC;Lau C;Ng C;Smith JS;Roberts SM
关于全氟烷基和多氟烷基物质对环境和人类健康影响的报告在同行评审文献中大大增加。本审查的目标是评估全氟辛烷磺酸毒理学影响的科学状况，并制定战略，以提高对这一大家族化学品健康影响的认识。目前，可获得的全氟辛烷磺酸毒性数据大多针对少数化学品，主要是全氟辛酸和全氟辛烷磺酸等传统全氟辛烷磺酸。流行病学研究揭示了暴露于特定PFAS与各种健康影响之间的关联，包括免疫和甲状腺功能改变、肝脏疾病、脂质和胰岛素失调、肾脏疾病、不良生殖和发育结果以及癌症。与实验动物数据一致的存在许多这些影响。然而，信息的作用方式和不良后果的途径必须扩大，并在PFAS毒代动力学特性的深刻差异必须考虑在理解性别之间的差异，物种和生命阶段之间的反应。由于相对较少的示例化合物和商业上数百种其他PFAS缺乏毒性数据，因此提出了更现代和高通量的方法，如交叉阅读，分子动力学和蛋白质建模，以加速开发新兴和传统PFAS的毒性信息，单独和混合物。此外，考虑到从所提到的PFAS例子中已经知道的情况，可能需要适当程度的预防措施来保护人类健康。
Reports of environmental and human health impacts of per- and polyfluoroalkyl substances (PFAS) have greatly increased in the peer-reviewed literature. The goals of the present review are to assess the state of the science regarding toxicological effects of PFAS and to develop strategies for advancing knowledge on the health effects of this large family of chemicals. Currently, much of the toxicity data available for PFAS are for a handful of chemicals, primarily legacy PFAS such as perfluorooctanoic acid and perfluorooctane sulfonate. Epidemiological studies have revealed associations between exposure to specific PFAS and a variety of health effects, including altered immune and thyroid function, liver disease, lipid and insulin dysregulation, kidney disease, adverse reproductive and developmental outcomes, and cancer. Concordance with experimental animal data exists for many of these effects. However, information on modes of action and adverse outcome pathways must be expanded, and profound differences in PFAS toxicokinetic properties must be considered in understanding differences in responses between the sexes and among species and life stages. With many health effects noted for a relatively few example compounds and hundreds of other PFAS in commerce lacking toxicity data, more contemporary and high-throughput approaches such as read-across, molecular dynamics, and protein modeling are proposed to accelerate the development of toxicity information on emerging and legacy PFAS, individually and as mixtures. In addition, an appropriate degree of precaution, given what is already known from the PFAS examples noted, may be needed to protect human health.
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Fernald 社区队列中纵向血清全氟烷基物质 (PFAS) 水平与甲状腺激素、肾功能和体重指数测量之间的关联。
DOI：
10.1016/j.envpol.2018.07.042
发表时间：
2018-11
期刊：
Environmental pollution (Barking, Essex : 1987)
影响因子：
--
作者：
Blake BE;Pinney SM;Hines EP;Fenton SE;Ferguson KK
通讯作者：
Ferguson KK
影响因子：
8.3
作者：
Avanasi R;Shin HM;Vieira VM;Bartell SM
通讯作者：
Bartell SM
DOI：
10.3390/ijerph13010146
发表时间：
2016-01-20
影响因子：
--
作者：
Ashley-Martin J;Dodds L;Arbuckle TE;Morisset AS;Fisher M;Bouchard MF;Shapiro GD;Ettinger AS;Monnier P;Dallaire R;Taback S;Fraser W
通讯作者：
Fraser W
影响因子：
11.8
作者：
Alderete, Tanya L.;Jin, Ran;Chatzi, Lida
通讯作者：
Chatzi, Lida
影响因子：
3.8
作者：
Bijland, Silvia;Rensen, Patrick C. N.;Princen, Hans M. G.
通讯作者：
Princen, Hans M. G.