Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection
Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection
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对肺树突状细胞进行抗体靶向疫苗接种可产生组织驻留记忆 CD8 T 细胞，对流感病毒感染具有高度保护作用
作者：
L. Wakim;Joanna Smith;I. Caminschi;M. Lahoud;J. Villadangos
流感病毒通过吸入进入体内，并在肺部启动其复制周期。感染的早期阶段，虽然病毒局限于肺粘膜，但为有效的免疫反应控制感染提供了理想的机会之窗。组织驻留记忆 (Trm) CD8 T 细胞位于包括肺在内的多种组织中，非常适合在此窗口期间发挥作用并阻止感染。参与肺 Trm 细胞分化的因素仍不清楚。我们证明，识别树突状细胞（DC）局部呈递的抗原和转化生长因子-β（TGFβ）信号传导都是必需的。我们利用这些知识开发了一种抗体靶向疫苗接种方法来产生肺 Trm 细胞。将抗原专门递送至呼吸道 DC 会导致肺部 CD8 Trm 细胞的发育，这些细胞对致命的流感攻击具有高度保护作用。我们的结果描述了一种有效的疫苗接种策略，可以预防流感病毒感染。
Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of infection, while the virus is confined to the lung mucosa, provides the ideal window of opportunity for an effective immune response to control the infection. Tissue-resident memory (Trm) CD8 T cells, located in a variety of tissues including the lung, are ideally situated to act during this window and stall the infection. The factors involved in the differentiation of lung Trm cells remain poorly defined. We demonstrate that recognition of antigen presented locally by dendritic cells (DCs) and transforming growth factor-β (TGFβ) signaling are both required. We exploited this knowledge to develop an antibody-targeted vaccination approach to generate lung Trm cells. Delivering antigen exclusively to respiratory DCs results in the development of lung CD8 Trm cells that are highly protective against lethal influenza challenge. Our results describe an effective vaccination strategy that protects against influenza virus infection.
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DOI：
10.1073/pnas.82.6.1785
发表时间：
1985-01-01
影响因子：
11.1
作者：
YEWDELL, JW;BENNINK, JR;MOSS, B
通讯作者：
MOSS, B
影响因子：
4.4
作者：
S. Liang;K. Mozdzanowska;G. Palladino;W. Gerhard
通讯作者：
S. Liang;K. Mozdzanowska;G. Palladino;W. Gerhard
影响因子：
32.4
作者：
Yu CI;Becker C;Wang Y;Marches F;Helft J;Leboeuf M;Anguiano E;Pourpe S;Goller K;Pascual V;Banchereau J;Merad M;Palucka K
通讯作者：
Palucka K
影响因子：
32.4
作者：
Kohlmeier, Jacob E.;Miller, Shannon C.;Smith, Joanna;Lu, Bao;Gerard, Craig;Cookenham, Tres;Roberts, Alan D.;Woodland, David L.
通讯作者：
Woodland, David L.