Probing the Brain-Body Connection Using Transcranial Magnetic Stimulation (TMS): Validating a Promising Tool to Provide Biomarkers of Neuroplasticity and Central Nervous System Function.
Probing the Brain-Body Connection Using Transcranial Magnetic Stimulation (TMS): Validating a Promising Tool to Provide Biomarkers of Neuroplasticity and Central Nervous System Function.
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DOI：
10.3390/brainsci11030384
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发表时间：
2021-03-17
期刊：
影响因子：
3.3
通讯作者：
Ploughman M
中科院分区：
文献类型：
--
作者：
Chaves AR;Snow NJ;Alcock LR;Ploughman M
经颅磁刺激（TMS）是一种用于研究人类神经运动系统神经生理完整性的非侵入性方法。我们详细描述了在大量多发性硬化症（MS）患者（n = 110）中进行的单脉冲TMS方案的方法。目的是建立和验证一组预测典型MS临床结果的TMS变量的核心集：步行速度，手部灵活性，疲劳和认知处理速度。我们提供了一个简短和简单的方法管道来检查兴奋性和抑制性皮质脊髓机制在MS映射到临床状态。延迟和较长的同侧沉默期（经胼胝体抑制的测量;一个大脑半球的活动对另一个大脑半球的影响），较长的皮质沉默期（提示通过GABA的更大的皮质脊髓抑制）和更高的静息运动阈值（较低的皮质脊髓兴奋性）与临床结果最密切相关，特别是当在对应于较弱的手的半球中测量时。半球间不对称性越大（半球之间的不平衡），在最大数量的临床结局中表现越差。我们还表明，毫不奇怪，TMS变量与运动结果的相关性比非运动结果更强。由于其在具有不同严重程度的中枢神经系统功能障碍的患者的大样本中得到验证，因此本文所述的方案可以由研究者和临床医生等使用以研究TMS作为MS和其他中枢神经系统病症中的生物标志物的作用。
Transcranial magnetic stimulation (TMS) is a non-invasive method used to investigate neurophysiological integrity of the human neuromotor system. We describe in detail, the methodology of a single pulse TMS protocol that was performed in a large cohort of people (n = 110) with multiple sclerosis (MS). The aim was to establish and validate a core-set of TMS variables that predicted typical MS clinical outcomes: walking speed, hand dexterity, fatigue, and cognitive processing speed. We provide a brief and simple methodological pipeline to examine excitatory and inhibitory corticospinal mechanisms in MS that map to clinical status. Delayed and longer ipsilateral silent period (a measure of transcallosal inhibition; the influence of one brain hemisphere’s activity over the other), longer cortical silent period (suggestive of greater corticospinal inhibition via GABA) and higher resting motor threshold (lower corticospinal excitability) most strongly related to clinical outcomes, especially when measured in the hemisphere corresponding to the weaker hand. Greater interhemispheric asymmetry (imbalance between hemispheres) correlated with poorer performance in the greatest number of clinical outcomes. We also show, not surprisingly, that TMS variables related more strongly to motor outcomes than non-motor outcomes. As it was validated in a large sample of patients with varying severities of central nervous system dysfunction, the protocol described herein can be used by investigators and clinicians alike to investigate the role of TMS as a biomarker in MS and other central nervous system disorders.
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影响因子：
2.4
作者：
Bollaert, Rachel E.;Motl, Robert W.
通讯作者：
Motl, Robert W.
DOI：
10.1590/s1807-59322011001300002
发表时间：
2011
期刊：
Clinics (Sao Paulo, Brazil)
影响因子：
--
作者：
Bliss TV;Cooke SF
通讯作者：
Cooke SF
影响因子：
6.7
作者：
Bohannon, RW
通讯作者：
Bohannon, RW
DOI：
10.1016/0168-5597(93)90086-5
发表时间：
1993-02-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
CARAMIA, MD;DESIATO, MT;ROSSINI, PM
通讯作者：
ROSSINI, PM
影响因子：
3.5
作者：
Carotenuto, A.;Iodice, R.;Orefice, G.
通讯作者：
Orefice, G.