Long-term potentiation and long-term depression: a clinical perspective.
Long-term potentiation and long-term depression: a clinical perspective.
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DOI：
10.1590/s1807-59322011001300002
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Cooke SF
中科院分区：
文献类型：
--
作者：
Bliss TV;Cooke SF
长时程增强和长时程抑制是突触强度的持久变化，由特定的突触活动模式引起，作为中枢神经系统信息存储的细胞模型而受到广泛关注。对从脊髓到大脑皮层的许多大脑区域以及从无脊椎动物到人类的许多动物物种的研究表明，化学突触具有可靠的能力，可以响应各种诱导方案而发生持久的功效变化。除了生理相关性之外，长时程增强和抑制可能具有重要的临床应用。对这些过程背后的分子机制的日益深入的了解，以及非侵入性操纵大脑活动的技术进步，现在使我们处于利用长期增强和抑制以及其他形式的突触、细胞和电路可塑性来操纵人类神经系统突触强度的门槛。药物可用于消除或治疗病理性突触状态，非侵入性刺激装置可用于人为诱导突触可塑性，以改善因突触驱动中断而引起的状况。这些方法有望治疗各种神经系统疾病，包括神经性疼痛、癫痫、抑郁症、弱视、耳鸣和中风。
Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system. Work in a number of brain regions, from the spinal cord to the cerebral cortex, and in many animal species, ranging from invertebrates to humans, has demonstrated a reliable capacity for chemical synapses to undergo lasting changes in efficacy in response to a variety of induction protocols. In addition to their physiological relevance, long-term potentiation and depression may have important clinical applications. A growing insight into the molecular mechanisms underlying these processes, and technological advances in non-invasive manipulation of brain activity, now puts us at the threshold of harnessing long-term potentiation and depression and other forms of synaptic, cellular and circuit plasticity to manipulate synaptic strength in the human nervous system. Drugs may be used to erase or treat pathological synaptic states and non-invasive stimulation devices may be used to artificially induce synaptic plasticity to ameliorate conditions arising from disrupted synaptic drive. These approaches hold promise for the treatment of a variety of neurological conditions, including neuropathic pain, epilepsy, depression, amblyopia, tinnitus and stroke.
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DOI：
10.1016/j.neucli.2010.01.001
发表时间：
2010-03-01
影响因子：
3
作者：
Ahdab, R.;Ayache, S. S.;Lefaucheur, J. -P.
通讯作者：
Lefaucheur, J. -P.
影响因子：
64.8
作者：
BINDMAN, LJ;LIPPOLD, OCJ;REDFEARN, JW
通讯作者：
REDFEARN, JW
影响因子：
5.5
作者：
Cheeran, Binith;Talelli, Penelope;Rothwell, John C.
通讯作者：
Rothwell, John C.
影响因子：
5.5
作者：
BLISS, TVP;GARDNERM.AR
通讯作者：
GARDNERM.AR
影响因子：
5.5
作者：
BLISS, TVP;LOMO, T
通讯作者：
LOMO, T