A model 450 million years in the making: zebrafish and vertebrate immunity.
A model 450 million years in the making: zebrafish and vertebrate immunity.
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DOI：
10.1242/dmm.007138
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发表时间：
2012-01
影响因子：
4.3
通讯作者：
Trede NS
中科院分区：
文献类型：
--
作者：
Renshaw SA;Trede NS
自30年前首次出现以来，斑马鱼模型的使用已经从早期脊椎动物发育的遗传解剖工具扩展到器官发生和疾病过程（如感染和癌症）的功能询问。特别是，科学界最近越来越关注斑马鱼的免疫系统。这一发展是基于能够在整个脊椎动物有机体中成像细胞运动和器官发生的能力，同时也越来越多地认识到斑马鱼和脊椎动物的免疫有许多共同之处。在这里，我们回顾了斑马鱼的免疫，特别关注最近的研究，利用独特的遗传和体内成像优势，可用于这种生物。这些独特的优势正在推动我们对脊椎动物免疫的研究，对理解哺乳动物免疫功能及其在疾病发病机制中的作用具有重要意义。
Since its first splash 30 years ago, the use of the zebrafish model has been extended from a tool for genetic dissection of early vertebrate development to the functional interrogation of organogenesis and disease processes such as infection and cancer. In particular, there is recent and growing attention in the scientific community directed at the immune systems of zebrafish. This development is based on the ability to image cell movements and organogenesis in an entire vertebrate organism, complemented by increasing recognition that zebrafish and vertebrate immunity have many aspects in common. Here, we review zebrafish immunity with a particular focus on recent studies that exploit the unique genetic and in vivo imaging advantages available for this organism. These unique advantages are driving forward our study of vertebrate immunity in general, with important consequences for the understanding of mammalian immune function and its role in disease pathogenesis.
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