Comparing different approaches for operationalizing subjective cognitive decline: impact on syndromic and biomarker profiles.
Comparing different approaches for operationalizing subjective cognitive decline: impact on syndromic and biomarker profiles.
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DOI：
10.1038/s41598-021-83428-1
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发表时间：
2021-02-23
影响因子：
4.6
通讯作者：
Westman E
中科院分区：
文献类型：
--
作者：
Diaz-Galvan P;Ferreira D;Cedres N;Falahati F;Hernández-Cabrera JA;Ames D;Barroso J;Westman E
主观认知能力下降（SCD）被认为是未来认知能力下降和痴呆的危险因素。鉴于 SCD 的异质性以及如何对这种情况进行分类缺乏共识，仍需要对不同的操作方法进行比较。在这项研究中，我们使用相同的个体样本来比较不同的 SCD 操作方法。我们从社区队列中纳入了 399 名认知健康的个体。 SCD 通过九个有关记忆和非记忆主观抱怨的问题进行评估。我们应用了四种方法来实施 SCD：两种假设驱动方法和两种数据驱动方法。我们使用综合人口统计、临床、认知和神经影像数据的多变量方法对每种操作方法产生的群体进行了表征。我们确定了两种主要表型：以阿尔茨海默病（AD）脑萎缩特征模式为特征的遗忘表型；以及主要与脑血管病理相关的异常表型。此外，除了命名之外的语言抱怨有助于识别具有亚临床认知障碍和日常生活活动困难的亚组。该亚组还表现出 AD 特征的萎缩模式。 SCD 表型的识别以不同的综合征和生物标志物特征为特征，根据所使用的操作方法而有所不同。在本研究中，我们讨论如何将这些发现应用于临床实践和研究。
Subjective cognitive decline (SCD) has been proposed as a risk factor for future cognitive decline and dementia. Given the heterogeneity of SCD and the lack of consensus about how to classify this condition, different operationalization approaches still need to be compared. In this study, we used the same sample of individuals to compare different SCD operationalization approaches. We included 399 cognitively healthy individuals from a community-based cohort. SCD was assessed through nine questions about memory and non-memory subjective complaints. We applied four approaches to operationalize SCD: two hypothesis-driven approaches and two data-driven approaches. We characterized the resulting groups from each operationalization approach using multivariate methods on comprehensive demographic, clinical, cognitive, and neuroimaging data. We identified two main phenotypes: an amnestic phenotype characterized by an Alzheimer’s Disease (AD) signature pattern of brain atrophy; and an anomic phenotype, which was mainly related to cerebrovascular pathology. Furthermore, language complaints other than naming helped to identify a subgroup with subclinical cognitive impairment and difficulties in activities of daily living. This subgroup also showed an AD signature pattern of atrophy. The identification of SCD phenotypes, characterized by different syndromic and biomarker profiles, varies depending on the operationalization approach used. In this study we discuss how these findings may be used in clinical practice and research.
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影响因子：
2.7
作者：
Falahati F;Ferreira D;Soininen H;Mecocci P;Vellas B;Tsolaki M;Kłoszewska I;Lovestone S;Eriksdotter M;Wahlund LO;Simmons A;Westman E;AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative
影响因子：
4.2
作者：
Ferreira, Daniel;Molina, Yaiza;Barroso, Jose
通讯作者：
Barroso, Jose
影响因子：
5.2
作者：
Cedres, Nira;Ferreira, Daniel;Westman, Eric
通讯作者：
Westman, Eric
影响因子：
9.9
作者：
Busse, A.;Hensel, A.;Riedel-Heller, S. G.
通讯作者：
Riedel-Heller, S. G.
影响因子：
8.3
作者：
Benedictus, Marije R.;van Harten, Argonde C.;van der Flier, Wiesje M.
通讯作者：
van der Flier, Wiesje M.