A specific area of olfactory cortex involved in stress hormone responses to predator odours.
A specific area of olfactory cortex involved in stress hormone responses to predator odours.
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DOI：
10.1038/nature17156
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发表时间：
2016-04-07
期刊：
影响因子：
64.8
通讯作者：
Buck, Linda B.
中科院分区：
文献类型：
--
作者：
Kondoh, Kunio;Lu, Zhonghua;Ye, Xiaolan;Olson, David P.;Lowell, Bradford B.;Buck, Linda B.
Instinctive reactions to danger are critical to the perpetuation of species and are observed throughout the animal kingdom. The scent of predators induces an instinctive fear response in mice that includes behavioral changes as well as a surge in blood stress hormones that mobilizes multiple body systems to escape impending danger. How the olfactory system routes predator signals detected in the nose to achieve these effects is unknown. Here we identify a specific area of the olfactory cortex that induces stress hormone responses to volatile predator odors. Using monosynaptic and polysynaptic viral tracers, we found that multiple olfactory cortical areas transmit signals to hypothalamic CRH (corticotropin releasing hormone) neurons, which control stress hormone levels. However, only one minor cortical area, the amygdalo-piriform transition area (AmPir), contained neurons upstream of CRH neurons that were activated by volatile predator odors. Chemogenetic stimulation of AmPir activated CRH neurons and induced an increase in blood stress hormone, mimicking an instinctive fear response. Moreover, chemogenetic silencing of AmPir markedly reduced the stress hormone response to predator odors without affecting a fear behavior. These findings suggest that AmPir, a small area comprising <5% of the olfactory cortex, plays a key role in the hormonal component of the instinctive fear response to volatile predator scents.
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影响因子：
64.5
作者：
Papes F;Logan DW;Stowers L
通讯作者：
Stowers L
DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
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通讯作者：
Roth, Bryan L.
影响因子：
64.8
作者：
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通讯作者：
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影响因子：
8.2
作者：
Apfelbach, R;Blanchard, CD;McGregor, IS
通讯作者：
McGregor, IS
影响因子：
64.5
作者：
Mombaerts, P;Wang, F;Axel, R
通讯作者：
Axel, R