3D bioprinting of complex tissues in vitro: state-of-the-art and future perspectives.
3D bioprinting of complex tissues in vitro: state-of-the-art and future perspectives.
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DOI：
10.1007/s00204-021-03212-y
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发表时间：
2022-03
影响因子：
6.1
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Xiang Y;Miller K;Guan J;Kiratitanaporn W;Tang M;Chen S
随着越来越多的复杂人体组织体外模型的建立，各种疗法和化学物质的药理学和毒理学都有了显著的改善。3D生物打印提供了对细胞数量、细胞外基质(ECM)沉积、动态微环境和复杂微结构的通用和精确控制，这是复杂组织体外建模所必需的，3D生物打印是一项快速发展的技术，将在该领域应用。在这篇综述中，我们将讨论印刷技术和生物墨水来源的最新进展，这是由于对建模策略的日益增长的需求所推动的，并促进了精细组织模型和建模策略的发展，随后是关于癌症、心脏、肌肉和肝脏的专门工作的最新进展。最后，对3D打印组织模型的毒理学建模策略、实质性挑战和未来前景进行了探讨。
The pharmacology and toxicology of a broad variety of therapies and chemicals have significantly improved with the aid of the increasing in vitro models of complex human tissues. Offering versatile and precise control over the cell population, extracellular matrix (ECM) deposition, dynamic microenvironment, and sophisticated microarchitecture, which is desired for the in vitro modeling of complex tissues, 3D bio-printing is a rapidly growing technology to be employed in the field. In this review, we will discuss the recent advancement of printing techniques and bio-ink sources, which have been spurred on by the increasing demand for modeling tactics and have facilitated the development of the refined tissue models as well as the modeling strategies, followed by a state-of-the-art update on the specialized work on cancer, heart, muscle and liver. In the end, the toxicological modeling strategies, substantial challenges, and future perspectives for 3D printed tissue models were explored.
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影响因子：
6.1
作者：
Grosberg A;Alford PW;McCain ML;Parker KK
通讯作者：
Parker KK
影响因子：
9
作者：
Goulart, Ernesto;de Caires-Junior, Luiz Carlos;Zatz, Mayana
通讯作者：
Zatz, Mayana
DOI：
10.1126/science.aav9750
发表时间：
2019-05-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Grigoryan B;Paulsen SJ;Corbett DC;Sazer DW;Fortin CL;Zaita AJ;Greenfield PT;Calafat NJ;Gounley JP;Ta AH;Johansson F;Randles A;Rosenkrantz JE;Louis-Rosenberg JD;Galie PA;Stevens KR;Miller JS
通讯作者：
Miller JS
影响因子：
4.7
作者：
Duchamp, Margaux;Liu, Tingting;Zhang, Yu Shrike
通讯作者：
Zhang, Yu Shrike
影响因子：
4.9
作者：
Cammarata, Christopher R.;Hughes, Mitchell E.;Ofner, Clyde M., III
通讯作者：
Ofner, Clyde M., III