Terminology for neuroscience data discovery: multi-tree syntax and investigator-derived semantics.

Terminology for neuroscience data discovery: multi-tree syntax and investigator-derived semantics.
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DOI:
10.1007/s12021-008-9029-7
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发表时间:
2008-09
期刊:
影响因子:
3
通讯作者:
Gardner, Esther P.
Gardner, Esther P.
中科院分区:
医学4区
文献类型:
--
作者:
Gardner, Daniel;Goldberg, David H.;Grafstein, Bernice;Robert, Adrian;Gardner, Esther P.

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神经科学信息框架(NIF)是为NIH神经科学研究蓝图开发的,可在http://nif.nih.gov和http://neurogateway.org上获得,它建立在一组协调的术语组件之上,使数据和网络资源描述和选择成为可能。核心NIF术语使用简单的语法,旨在方便使用和熟悉的Web界面导航,并易于导出,以帮助开发神经科学数据共享的关系模型数据库。数据集、数据分析工具、网络资源和其他实体的特征在于多个描述符,每个描述符都涉及核心概念,包括数据类型、采集技术、神经解剖学和细胞类别。每个概念的术语被组织在树结构中,提供is-a和has-a关系。每个词根附近的宽泛的通用术语跨越了类别或概念,并产生了更详细的条目。相关但不同的概念(例如,大脑区域和深度)由单独的树指定,以便比图形表示所需的导航更容易。在一个或多个研讨会上,由特定系统(视觉,嗅觉,行为神经科学,神经发育),大脑区域(小脑,丘脑,海马),制剂(软体动物,苍蝇),疾病(神经退行性疾病)或技术(显微镜,计算和建模,神经遗传学)的研究专家选择语义NIF数据发现。研讨会衍生的综合术语列表可在http://brainml.org上获得开源;完整的参与者列表可在http://brainml.org/workshops上获得。
The Neuroscience Information Framework (NIF), developed for the NIH Blueprint for Neuroscience Research and available at http://nif.nih.gov and http://neurogateway.org, is built upon a set of coordinated terminology components enabling data and web-resource description and selection. Core NIF terminologies use a straightforward syntax designed for ease of use and for navigation by familiar web interfaces, and readily exportable to aid development of relational-model databases for neuroscience data sharing. Datasets, data analysis tools, web resources, and other entities are characterized by multiple descriptors, each addressing core concepts, including data type, acquisition technique, neuroanatomy, and cell class. Terms for each concept are organized in a tree structure, providing is-a and has-a relations. Broad general terms near each root span the category or concept and spawn more detailed entries for specificity. Related but distinct concepts (e.g., brain area and depth) are specified by separate trees, for easier navigation than would be required by graph representation. Semantics enabling NIF data discovery were selected at one or more workshops by investigators expert in particular systems (vision, olfaction, behavioral neuroscience, neurodevelopment), brain areas (cerebellum, thalamus, hippocampus), preparations (molluscs, fly), diseases (neurodegenerative disease), or techniques (microscopy, computation and modeling, neurogenetics). Workshop-derived integrated term lists are available Open Source at http://brainml.org; a complete list of participants is at http://brainml.org/workshops.
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