Naming impairment in Alzheimer's disease is associated with left anterior temporal lobe atrophy.
Naming impairment in Alzheimer's disease is associated with left anterior temporal lobe atrophy.
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DOI：
10.1016/j.neuroimage.2012.06.018
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发表时间：
2012-10-15
期刊：
影响因子：
5.7
通讯作者：
Dickerson, Bradford C.
中科院分区：
文献类型：
--
作者：
Domoto-Reilly, Kimiko;Sapolsky, Daisy;Brickhouse, Michael;Dickerson, Bradford C.
关键词：
关于语义记忆的神经解剖学定位存在相当大的争论，语义记忆是关于文化共享元素的知识，如物体，概念和人。最近的两项功能成像研究（fMRI和PET）的荟萃分析试图确定参与语义处理的皮层区域。宾德和同事们确定了几个感兴趣的区域，广泛分布在额叶、顶叶和颞叶皮层。相反，聚焦于前颞叶，发现当考虑到信号丢失的可能性时（例如，由于失真伪影或视野限制），检测到显著的区域激活。我们着手确定前颞叶是否在图片命名中起着重要作用，这是一项依赖于语义记忆的任务。我们研究了一个相对较大的样本，早期阿尔茨海默氏病患者（N=145），一个多灶性疾病的过程，其特点是在早期阶段的问题，情节记忆和执行功能。基于来自荟萃分析的感兴趣区域的假设驱动分析以及整个大脑皮层的探索性分析表明，左前颞叶皮层变薄与命名能力受损之间存在高度特异性相关性。这些发现进一步支持了一些理论，包括前颞叶在依赖语义记忆的任务中的重要作用。
There is considerable debate about the neuroanatomic localization of semantic memory, the knowledge of culturally shared elements such as objects, concepts, and people. Two recent meta-analyses of functional imaging studies (fMRI and PET) sought to identify cortical regions involved in semantic processing. Binder and colleagues identified several regions of interest, widely distributed throughout the frontal, parietal, and temporal cortices. In contrast, focused on the anterior temporal lobe, and found that when the potential for signal loss is accounted for (due, for example, to distortion artifact or field of view restriction), significant regional activation is detected. We set out to determine whether the anterior temporal lobe plays a significant role in picture naming, a task which relies on semantic memory. We examined a relatively large sample of patients with early Alzheimer’s disease (N=145), a multifocal disease process typically characterized in the early stages by problems with episodic memory and executive function. Hypothesis-driven analyses based on regions of interest derived from the meta-analyses as well as exploratory analyses across the entire cerebral cortex demonstrated a highly specific correlation between cortical thinning of the left anterior temporal lobe and impaired naming performance. These findings lend further support to theories that include a prominent role for the anterior temporal lobe in tasks that rely on semantic memory.
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