Influence of nerve cuff channel count and implantation site on the separability of afferent ENG.
Influence of nerve cuff channel count and implantation site on the separability of afferent ENG.
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DOI：
10.1088/1741-2552/aabca0
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发表时间：
2018-08
影响因子：
4
通讯作者：
Nazarpour K
中科院分区：
文献类型：
--
作者：
Silveira C;Brunton E;Spendiff S;Nazarpour K
Objective.记录脊髓损伤患者或中风幸存者的完整外周神经的神经信号为闭环感觉运动假体的开发提供了可能性。已经发现神经袖带提供来自外周神经的长时间段的稳定记录。然而，在神经袖带的设计和定位上仍然存在问题，使得从外周神经记录的神经数据的可分离性得到改善。Approach.在大鼠坐骨神经上放置神经袖带，记录传入神经电图（ENG）信号，以响应对后爪的各种机械刺激。提取信号的平均绝对值并输入到分类器。在两种情况下评估分类器的性能：（1）当使用来自3通道或16通道袖带的信息时;（2）当信息可从沿神经沿着远端或近端放置的袖带获得时。主要结果。我们表明，3和16通道袖带能够分离传入ENG信号的准确性大于机会。最高的分类分数时，分类器被送入从远端放置的16通道袖带获得的信息。虽然16通道袖带的性能始终优于3通道袖带，但当将16通道袖带放置在神经远端而不是近端时，性能差异会增加。意义结果表明，增加神经套囊的复杂性可能只有在神经套囊被植入远端时才是有利的，其中神经已经开始分成单独的神经束。
Objective. Recording of neural signals from intact peripheral nerves in patients with spinal cord injury or stroke survivors offers the possibility for the development of closed-loop sensorimotor prostheses. Nerve cuffs have been found to provide stable recordings from peripheral nerves for prolonged periods of time. However, questions remain over the design and positioning of nerve cuffs such that the separability of neural data recorded from the peripheral nerves is improved. Approach. Afferent electroneurographic (ENG) signals were recorded with nerve cuffs placed on the sciatic nerve of rats in response to various mechanical stimuli to the hindpaw. The mean absolute value of the signal was extracted and input to a classifier. The performance of the classifier was evaluated under two conditions: (1) when information from either a 3- or 16-channel cuff was used; (2) when information was available from a cuff placed either distally or proximally along the nerve. Main results. We show that both 3- and 16-channel cuffs were able to separate afferent ENG signals with an accuracy greater than chance. The highest classification scores were achieved when the classifier was fed with information obtained from a 16-channel cuff placed distally. While the 16-channel cuff always outperformed the 3-channel cuff, the difference in performance was increased when the 16-channel cuff was placed distally rather than proximally on the nerve. Significance. The results indicate that increasing the complexity of a nerve cuff may only be advantageous if the nerve cuff is to be implanted distally, where the nerve has begun to divide into individual fascicles.
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DOI：
10.1109/tnsre.2014.2355856
发表时间：
2015-05
期刊：
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Pistohl T;Joshi D;Ganesh G;Jackson A;Nazarpour K
通讯作者：
Nazarpour K
影响因子：
4.6
作者：
D'Anna E;Petrini FM;Artoni F;Popovic I;Simanić I;Raspopovic S;Micera S
通讯作者：
Micera S
影响因子：
1.2
作者：
Schiefer, Matthew A.;Tyler, Dustin J.;Triolo, Ronald J.
通讯作者：
Triolo, Ronald J.
影响因子：
12.7
作者：
Larsen, JO;Thomsen, M;Sinkjaer, T
通讯作者：
Sinkjaer, T
影响因子：
4
作者：
Cutrone, A.;Del Valle, J.;Bossi, S.
通讯作者：
Bossi, S.