Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials.
Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials.
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DOI：
10.3390/antibiotics10101216
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发表时间：
2021-10-07
期刊：
影响因子：
--
通讯作者：
Tardy F
中科院分区：
文献类型：
--
作者：
Pereyre S;Tardy F
支原体感染在人类和许多动物中都很常见。然而，抗菌治疗的选择是有限的，部分原因是这些特殊细菌缺乏细胞壁。兽药和人用药都面临着最常用药物耐药性日益增加的问题，尽管使用做法不同。迄今为止，很少有综述整合了人类和动物对抗微生物药物耐药性的知识，最新的综述可追溯到2014年。为了填补这一空白，我们同时研究了抗菌素使用、耐药机制、基于表型或基因型的抗菌素药敏试验方法，以及最具临床相关性的人类和动物支原体物种的耐药流行病学。这次审查揭示了在“同一个健康”的观点中需要考虑的共同特点和差异。最后，强调了多重耐药的两个严重病例，即人类生殖支原体和动物牛支原体，两者都可能导致无法治愈的感染威胁。
Mycoplasma infections are frequent in humans, as well as in a broad range of animals. However, antimicrobial treatment options are limited, partly due to the lack of a cell wall in these peculiar bacteria. Both veterinary and human medicines are facing increasing resistance prevalence for the most commonly used drugs, despite different usage practices. To date, very few reviews have integrated knowledge on resistance to antimicrobials in humans and animals, the latest dating back to 2014. To fill this gap, we examined, in parallel, antimicrobial usage, resistance mechanisms and either phenotype or genotype-based methods for antimicrobial susceptibility testing, as well as epidemiology of resistance of the most clinically relevant human and animal mycoplasma species. This review unveiled common features and differences that need to be taken into consideration in a “One Health” perspective. Lastly, two examples of critical cases of multiple drug resistance are highlighted, namely, the human M. genitalium and the animal M. bovis species, both of which can lead to the threat of untreatable infections.
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影响因子：
3.2
作者：
Becker, Claire A. M.;Thibault, Francois M.;Tardy, Florence
通讯作者：
Tardy, Florence
影响因子：
11.8
作者：
Bercot, Beatrice;Charreau, Isabelle;Molina, Jean-Michel
通讯作者：
Molina, Jean-Michel
影响因子：
9.4
作者：
Aquilino, Ana;Masia, Mar;Gutierrez, Felix
通讯作者：
Gutierrez, Felix
影响因子：
3.7
作者：
Bekő K;Kreizinger Z;Yvon C;Saller O;Catania S;Feberwee A;Gyuranecz M
通讯作者：
Gyuranecz M
影响因子：
4.5
作者：
Blanco P;Hernando-Amado S;Reales-Calderon JA;Corona F;Lira F;Alcalde-Rico M;Bernardini A;Sanchez MB;Martinez JL
通讯作者：
Martinez JL