Anthropometric factors, physical activity, and risk of non-Hodgkin's lymphoma in the Women's Health Initiative.
Anthropometric factors, physical activity, and risk of non-Hodgkin's lymphoma in the Women's Health Initiative.
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DOI：
10.1016/j.canep.2011.05.014
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发表时间：
2012-02
影响因子：
2.6
通讯作者：
Rohan TE
中科院分区：
文献类型：
--
作者：
Kabat GC;Kim MY;Jean-Wactawski-Wende;Bea JW;Edlefsen KL;Adams-Campbell LL;De Roos AJ;Rohan TE
20 世纪下半叶，美国和世界范围内非霍奇金淋巴瘤 (NHL) 的发病率大幅上升，但对其病因却知之甚少。肥胖与免疫功能受损有关，从而可能影响 NHL 的风险；反映能量稳态的其他因素（身高、腹部肥胖和体力活动）也可能参与其中。我们在 1993 年至 1998 年间在美国 40 个临床中心登记的一大批 50-79 岁的女性中，研究了人体测量因素和体力活动与 NHL 及其主要亚型风险之间的关系。在平均 11 年的随访期内，在 158,975 名女性中发现了 1123 例 NHL 病例。 Cox 比例风险模型用于估计风险比 (HR) 和 95% 置信区间 (CI)。基线身高与所有 NHL 和弥漫性大 B 细胞淋巴瘤的风险呈正相关（HRsq4vs.q1 1.19，95% CI 1.00-1.43 和 1.43，95% CI 1.01-2.03）。基线肥胖和腹部肥胖的测量与风险无关。 18 岁时，体重和体重指数最高四分位的女性的 NHL 风险比增加（HRsq4vs.q1 分别为 1.29，95% CI 1.01–1.65 和 1.27，95% CI 1.01–1.59）。一些娱乐性体育活动指标与 NHL 总体风险增加有一定关联，但与特定亚型没有明显关联。我们关于人体测量指标的研究结果与之前的几份报告一致，表明生命早期对生长和免疫功能的影响可能会影响晚年患 NHL 的风险。
Incidence rates of non-Hodgkin’s lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20th century, but little is known about its etiology. Obesity is associated with impaired immune function through which it may influence the risk of NHL; other factors reflecting energy homeostasis (height, abdominal adiposity, and physical activity) may also be involved. We examined the association of anthropometric factors and physical activity with risk of NHL and its major subtypes in a large cohort of women aged 50–79 years old who were enrolled at 40 clinical centers in the United States between 1993 and 1998. Over a mean follow-up period of 11 years, 1123 cases of NHL were identified among 158,975 women. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Height at baseline was positively associated with risk of all NHL and with that of diffuse large B-cell lymphoma (HRsq4vs.q1 1.19, 95% CI 1.00–1.43 and 1.43, 95% CI 1.01–2.03, respectively). Measures of obesity and abdominal adiposity at baseline were not associated with risk. Hazard ratios for NHL were increased for women in the highest quartile of weight and body mass index at age 18 (HRsq4vs.q1 1.29, 95% CI 1.01–1.65 and 1.27, 95% CI 1.01–1.59, respectively). Some measures of recreational physical activity were modestly associated with increased risk of NHL overall, but there were no clear associations with specific subtypes. Our findings regarding anthropometric measures are consistent with those of several previous reports, suggesting that early life influences on growth and immune function may influence the risk of NHL later in life.
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影响因子：
64.8
作者：
BUCKBINDER, L;TALBOTT, R;KLEY, N
通讯作者：
KLEY, N
影响因子：
6.4
作者：
Fernberg, P;Odenbro, A;Adami, J
通讯作者：
Adami, J
影响因子：
2.3
作者：
De Roos, Anneclaire J.;Ulrich, Cornelia M.;LaCroix, Andrea Z.
通讯作者：
LaCroix, Andrea Z.
影响因子：
7.1
作者：
Hoppe, C;Udam, TR;Michaelsen, KF
通讯作者：
Michaelsen, KF
影响因子：
6.4
作者：
Bosetti, Cristina;Levi, Fabio;La Vecchia, Carlo
通讯作者：
La Vecchia, Carlo