Urinary interleukin-6 as a predictor of radiographic progression in rheumatoid arthritis: A 3-year evaluation.
Urinary interleukin-6 as a predictor of radiographic progression in rheumatoid arthritis: A 3-year evaluation.
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DOI：
10.1038/srep35242
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发表时间：
2016-10-12
影响因子：
4.6
通讯作者：
Kim WU
中科院分区：
文献类型：
--
作者：
Park YJ;Yoo SA;Kim GR;Cho CS;Kim WU
以前，我们证明了类风湿关节炎（RA）患者的尿蛋白质组特征反映了炎症相关的细胞过程。在这里，我们测量了RA患者尿液中白细胞介素（IL）-6，IL-8和趋化因子配体2（CCL 2）的浓度，并前瞻性地研究了它们在预测RA活动和预后中的作用。招募了173例RA患者和62例非RA对照。RA患者尿中IL-6、CCL 2和IL-8水平升高，并与疾病活动性密切相关。就诊时尿IL-6水平是1年和3年时放射学进展的独立风险因素。高尿IL-6水平使放射学进展的风险比增加2.9倍，这与高血清CRP相当。此外，尿IL-6和血清CRP联合检测可协同增加放射学进展的预测性。在ESR正常的亚组中，尿IL-6水平最高的患者放射学进展的风险高6.4倍。结论：高尿IL-6水平是RA放射学进展的独立危险因素，反映了疾病的活动性。尿IL-6联合血清CRP可作为判断RA预后的一个有用指标。
Previously, we demonstrated that the urine proteome signature of patients with rheumatoid arthritis (RA) reflects inflammation-related cellular processes. Here, we measured interleukin (IL)-6, IL-8, and chemokine ligand 2 (CCL2) concentrations in the urine of RA patients and prospectively investigated their role in predicting RA activity and prognosis. One hundred seventy-three RA patients and 62 non-RA controls were recruited. Urinary IL-6, CCL2, and IL-8 levels were elevated in RA patients and correlated well with disease activity. Urinary IL-6 level at presentation was an independent risk factor of radiographic progression at 1 and 3 years. High urinary IL-6 level increased the risk ratio of radiographic progression by 2.9-fold, which was comparable to high serum CRP. Moreover, combination of urinary IL-6 and serum CRP measures synergistically increased the predictability of radiographic progression. In a subgroup with normal ESR, patients with the highest tertile of urinary IL-6 were at 6.4-fold greater risk of radiographic progression. Conclusively, high urinary IL-6 level at presentation is an independent risk factor for radiographic progression of RA, reflecting disease activity. Urinary IL-6 in combination with serum CRP may be a useful parameter for estimating RA prognosis.
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影响因子：
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作者：
Aletaha D;Nell VP;Stamm T;Uffmann M;Pflugbeil S;Machold K;Smolen JS
通讯作者：
Smolen JS
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作者：
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