Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.
Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.
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DOI：
10.3389/fneur.2018.00517
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发表时间：
2018
影响因子：
3.4
通讯作者：
Baker SN
中科院分区：
文献类型：
--
作者：
Choudhury S;Singh R;Chatterjee P;Trivedi S;Shubham S;Baker MR;Kumar H;Baker SN
研究背景：书写痉挛（Writer 'scramp，WC）是一种因书写任务而引起的局部手部肌张力障碍，表现为书写时疼痛、僵硬和/或震颤。我们通过测量眨眼反射的肌间相干性（IMC）和前脉冲抑制（PPI）来探讨皮层和脑干回路的参与。研究方法：在10名健康对照和20名WC患者（10名伴有震颤）中测量IMC，同时他们在不同的力水平下执行精确抓握任务。通过刺激右侧眶上神经和记录双侧眼轮匝肌的表面肌电图，对9名健康对照和10名WC患者的眨眼反应进行了评价。PPI涉及用对右正中神经的先前电击（100 ms间隔）调节该刺激，并测量眨眼反射的R2分量的减少。结果：WC患者在3-7 Hz处存在显著的IMC，而健康对照者则不存在。与健康对照组相比，WC患者的眨眼反射的R2分量显示PPI显著降低。3-7 Hz的IMC可以可靠地区分WC患者和健康对照。结论：产生θ波（3-7 Hz）的皮层或皮层下回路可能在WC的发病中起重要作用。此外，PPI的缺乏暗示了WC出现时脑干抑制的异常。IMC可能值得进一步发展为局灶性肌张力障碍的电诊断试验。
Background: Writer's cramp (WC) is a task-specific focal hand dystonia presenting with pain, stiffness and/or tremor while writing. We explored the involvement of cortical and brainstem circuits by measuring intermuscular coherence (IMC) and pre-pulse inhibition (PPI) of the blink reflex. Methods: IMC was measured in 10 healthy controls and 20 WC patients (10 with associated tremor) while they performed a precision grip task at different force levels. Blink responses were evaluated in 9 healthy controls and 10 WC patients by stimulating the right supraorbital nerve and recording surface EMG from the orbicularis oculi muscles bilaterally. PPI involved conditioning this stimulation with a prior shock to the right median nerve (100 ms interval), and measuring the reduction in the R2 component of the blink reflex. Results: Significant IMC at 3–7 Hz was present in WC patients, but not in healthy controls. Compared to healthy controls, in WC patients the R2 component of the blink reflex showed significantly less PPI. IMC at 3–7 Hz could reliably discriminate WC patients from healthy controls. Conclusion: Cortical or sub-cortical circuits generating theta (3–7 Hz) oscillations might play an important role in the pathogenesis of WC. Moreover, the lack of PPI implicates abnormalities in brainstem inhibition in the emergence of WC. IMC may merit further development as an electrodiagnostic test for focal dystonia.
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DOI：
10.1093/brain/aws150
发表时间：
2012-09
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Fisher KM;Zaaimi B;Williams TL;Baker SN;Baker MR
通讯作者：
Baker MR
影响因子：
9.9
作者：
MCDANIEL, KD;CUMMINGS, JL;SHAIN, S
通讯作者：
SHAIN, S
影响因子：
--
作者：
Butz, M;Timmermann, L;Schnitzler, A
通讯作者：
Schnitzler, A
影响因子：
8.6
作者：
Albanese, Alberto;Bhatia, Kailash;Bressman, Susan B.;DeLong, Mahlon R.;Fahn, Stanley;Fung, Victor S. C.;Hallett, Mark;Jankovic, Joseph;Jinnah, Hyder A.;Klein, Christine;Lang, Anthony E.;Mink, Jonathan W.;Teller, Jan K.
通讯作者：
Teller, Jan K.
影响因子：
4.4
作者：
Frauscher, Birgit;Loescher, Wolfgang N.;Kofler, Markus
通讯作者：
Kofler, Markus