Type 2 diabetes and the risk of renal cell cancer in women.
Type 2 diabetes and the risk of renal cell cancer in women.
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DOI：
10.2337/dc11-0132
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发表时间：
2011-07
期刊：
影响因子：
16.2
通讯作者：
Cho E
中科院分区：
文献类型：
--
作者：
Joh HK;Willett WC;Cho E
2型糖尿病与几种癌症的风险增加有关;然而，其与肾细胞癌的关系仍不清楚。在护士健康研究中，共有118，177名年龄在30至55岁之间的女性在基线（1976年）进行了随访，直到2008年。在基线时收集医生诊断的糖尿病的自我报告，每两年更新一次。使用考克斯比例风险模型计算风险比（HR），并校正年龄、BMI、高血压、吸烟和产次。在32年的随访期间（3，531，170人-年），记录了16，819例2型糖尿病和330例病理证实的肾细胞癌。多变量校正后，2型糖尿病与肾细胞癌风险增加显著相关（HR 1.60 [95% CI 1.19-2.17]）。这些关联在BMI、吸烟和高血压的不同分层中是一致的（P相互作用≥ 0.32）。肾细胞癌的风险随着合并症的增加而增加，包括肥胖、高血压和2型糖尿病（P趋势< 0.001）。与没有任何合并症的女性相比，患有所有三种疾病的女性患肾细胞癌的风险比为4.13（2.76-6.18）。2型糖尿病与女性肾细胞癌风险增加独立相关。此外，肥胖、高血压和2型糖尿病的合并症显著增加了肾细胞癌的风险。
Type 2 diabetes is associated with increased risks of several types of cancer; however, its relationship to renal cell cancer remains unclear. A total of 118,177 women aged 30 to 55 years at baseline (1976) were followed up through 2008 in the Nurses’ Health Study. Self-reports of physician-diagnosed diabetes were collected at baseline and updated biennially. Hazard ratios (HRs) were calculated using Cox proportional hazards models with adjustment for age, BMI, hypertension, smoking, and parity. During 32 years of follow-up (3,531,170 person-years), 16,819 cases of type 2 diabetes and 330 cases of pathology-confirmed incident renal cell cancer were documented. After multivariate adjustment, type 2 diabetes was significantly associated with an increased risk of renal cell cancer (HR 1.60 [95% CI 1.19–2.17]). These associations were consistent across different strata of BMI, smoking, and hypertension (Pinteraction ≥ 0.32). The risk of renal cell cancer increased with an increasing number of comorbidities, including obesity, hypertension, and type 2 diabetes (Ptrend < 0.001). When compared with women without any comorbidity, women who had all three conditions had a HR of 4.13 (2.76–6.18) for renal cell cancer. Type 2 diabetes is independently associated with an increased risk of renal cell cancer in women. In addition, comorbidity of obesity, hypertension, and type 2 diabetes substantially elevates the risk of renal cell cancer.
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影响因子：
16.2
作者：
Michels, KB;Solomon, CG;Manson, JE
通讯作者：
Manson, JE
影响因子：
5
作者：
Setiawan, Veronica Wendy;Stram, Daniel O.;Henderson, Brian E.
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50.5
作者：
Zucchetto, A.;Dal Maso, L.;La Vecchia, C.
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影响因子：
16.2
作者：
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通讯作者：
Yee D
DOI：
10.1007/s10552-010-9555-0
发表时间：
2010-08
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Flood A;Strayer L;Schairer C;Schatzkin A
通讯作者：
Schatzkin A