Lesion Area in the Cerebral Cortex Determines the Patterns of Axon Rewiring of Motor and Sensory Corticospinal Tracts After Stroke.
Lesion Area in the Cerebral Cortex Determines the Patterns of Axon Rewiring of Motor and Sensory Corticospinal Tracts After Stroke.
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DOI：
10.3389/fnins.2021.737034
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发表时间：
2021
影响因子：
4.3
通讯作者：
Ueno M
中科院分区：
文献类型：
--
作者：
Sato T;Nakamura Y;Takeda A;Ueno M
皮质脊髓束(CST)是脑损伤(如中风)后恢复运动功能的重要神经重组途径。CST包括来自大脑皮层不同感觉运动区的多条通路；然而，这种复杂通路在损伤后的重组模式在很大程度上是未知的。在这里，我们全面研究了多个大脑起源的CST通路在小鼠中风模型中的重新连接模式，该模型在感觉运动皮质中的大小和位置不同。我们发现，在卒中后的大片皮质区，备用的对侧运动和感觉CST轴突穿过中线，发芽进入失神经的颈髓一侧。相反，对侧CST纤维不会在小的卒中中萌发，而来自备用运动区的同侧轴突在失神经侧生长。我们进一步证明，当运动和感觉CST轴突之一受到损伤时，它们并不相互支配投射区域。本结果揭示了产生CST重连模式的基本原理，该模式取决于卒中位置和CST亚型。我们的数据表明，在不同类型的损伤中，靶向不同的神经底物以恢复功能的重要性。
The corticospinal tract (CST) is an essential neural pathway for reorganization that recovers motor functions after brain injuries such as stroke. CST comprises multiple pathways derived from different sensorimotor areas of the cerebral cortex; however, the patterns of reorganization in such complex pathways postinjury are largely unknown. Here we comprehensively examined the rewiring patterns of the CST pathways of multiple cerebral origins in a mouse stroke model that varied in size and location in the sensorimotor cortex. We found that spared contralesional motor and sensory CST axons crossed the midline and sprouted into the denervated side of the cervical spinal cord after stroke in a large cortical area. In contrast, the contralesional CST fibers did not sprout in a small stroke, whereas the ipsilesional axons from the spared motor area grew on the denervated side. We further showed that motor and sensory CST axons did not innervate the projecting areas mutually when either one was injured. The present results reveal the basic principles that generate the patterns of CST rewiring, which depend on stroke location and CST subtype. Our data indicate the importance of targeting different neural substrates to restore function among the types of injury.
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