Greater Reduction in Contralesional Hand Use After Frontoparietal Than Frontal Motor Cortex Lesions in Macaca mulatta.
Greater Reduction in Contralesional Hand Use After Frontoparietal Than Frontal Motor Cortex Lesions in Macaca mulatta.
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DOI：
10.3389/fnsys.2021.592235
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发表时间：
2021
影响因子：
3
通讯作者：
Morecraft RJ
中科院分区：
文献类型：
--
作者：
Darling WG;Pizzimenti MA;Rotella DL;Ge J;Stilwell-Morecraft KS;Morecraft RJ
我们之前报道过恒河猴在允许使用任何一只手的精细运动任务中进行减少使用（RU）测试时，在神经外科手术损伤手臂/手部初级运动皮层（M1）和外侧运动前皮层（LPMC） （F2损伤）后，恢复了更受损（对照）手的自发使用。损伤较轻的那只手没有受到限制，偶尔也会被迫使用受损较重的那只手，这只手在病变前是精细运动任务的首选手。在这里，我们比较了5例F2病变在相同RU测试中的恢复情况与单侧M1、LPMC、S1和顶叶前部病变后的恢复情况（F2P2病变- 4例）。F2组在RU任务中对侧手的平均使用率和最高使用率是F2P2组的2倍（p < 0.05）。在F2和F2P2病变病例中，RU任务的恢复与体积和病变到尾侧（新）M1 （M1c）的百分比密切相关。1例F2P2患者，其最大的M1c病变和较大的吻侧体感觉皮层（S1r）病变，尽管最初表现出一些精细运动功能的恢复，但仍出现严重的对偶性手部不能使用。我们得出结论，对侧手减少使用的程度主要与M1c损伤量有关，严重不使用需要广泛的M1c和S1r损伤。因此，评估脑卒中患者罗兰周围损伤程度可能对预测RU易感性和不用于康复具有预后价值。
We previously reported that rhesus monkeys recover spontaneous use of the more impaired (contralesional) hand following neurosurgical lesions to the arm/hand representations of primary motor cortex (M1) and lateral premotor cortex (LPMC) (F2 lesion) when tested for reduced use (RU) in a fine motor task allowing use of either hand. Recovery occurred without constraint of the less impaired hand and with occasional forced use of the more impaired hand, which was the preferred hand for use in fine motor tasks before the lesion. Here, we compared recovery of five F2 lesion cases in the same RU test to recovery after unilateral lesions of M1, LPMC, S1 and anterior portion of parietal cortex (F2P2 lesion – four cases). Average and highest %use of the contralesional hand in the RU task in F2 cases were twice that in F2P2 cases (p < 0.05). Recovery in the RU task was closely associated with volume and percentage of lesion to caudal (new) M1 (M1c) in both F2 and F2P2 lesion cases. One F2P2 case, with the largest M1c lesion and a large rostral somatosensory cortex (S1r) lesion developed severe contralesional hand non-use despite exhibiting some recovery of fine motor function initially. We conclude that the degree of reduced use of the contralesional hand is primarily related to the volume of M1c injury and that severe non-use requires extensive injury to M1c and S1r. Thus, assessing peri-Rolandic injury extent in stroke patients may have prognostic value for predicting susceptibility to RU and non-use in rehabilitation.
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影响因子：
5.3
作者：
Darling, Warren G.;Pizzimenti, Marc A.;Morecraft, Robert J.
通讯作者：
Morecraft, Robert J.
DOI：
10.1002/cne.22218
发表时间：
2010-03-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
McNeal DW;Darling WG;Ge J;Stilwell-Morecraft KS;Solon KM;Hynes SM;Pizzimenti MA;Rotella DL;Vanadurongvan T;Morecraft RJ
通讯作者：
Morecraft RJ
影响因子：
2.5
作者：
KANEKO, T;CARIA, MA;ASANUMA, H
通讯作者：
ASANUMA, H
DOI：
10.1093/brain/awx270
发表时间：
2017-11-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Catani M
通讯作者：
Catani M
影响因子：
2
作者：
Darling, Warren G.;Pizzimenti, Marc A.;Morecraft, Robert J.
通讯作者：
Morecraft, Robert J.