Recognition memory and theta-gamma interactions in the hippocampus.
Recognition memory and theta-gamma interactions in the hippocampus.
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DOI：
10.1002/hipo.22228
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发表时间：
2014-03
期刊：
影响因子：
3.5
通讯作者：
Manns, Joseph R.
中科院分区：
文献类型：
--
作者：
Trimper, John B.;Stefanescu, Roxana A.;Manns, Joseph R.
大鼠海马神经元振荡和交叉频率相互作用与记忆过程有重要关系，并可作为更广泛地研究认知中振荡活动的模型。我们在这里报告，海马同步性（CA 3-CA 1相干性）在低伽马范围内显着增加，大鼠正在探索新的对象，特别是那些大鼠随后表现出良好的记忆。伽马同步性在θ节律的各个阶段变化，使得相干性在θ波的下降斜率和波谷处最高。此外，与大鼠随后表现出较差记忆的对象相比，在探索大鼠随后表现出良好记忆的对象期间，θ波的形状更不对称并且在下降斜率处延长。结果表明，大鼠海马中事件相关的伽马同步性与对新物体的记忆编码之间存在很强的关联。此外，交叉频率相互作用的一种新的潜在机制被观察到，从而在与记忆相关的θ波的形状的动态变化对应于伽马同步的强度。这些发现增加了我们对海马体中θ和γ振荡如何在记忆服务中相互作用的理解。
Neuronal oscillations and cross-frequency interactions in the rat hippocampus relate in important ways to memory processes and serve as a model for studying oscillatory activity in cognition more broadly. We report here that hippocampal synchrony (CA3-CA1 coherence) increased markedly in the low gamma range as rats were exploring novel objects, particularly those for which the rat subsequently showed good memory. The gamma synchrony varied across phases of the theta rhythm such that coherence was highest at the falling slope and trough of the theta wave. Further, the shape of the theta wave was more asymmetric and elongated at the falling slope during exploration of objects for which the rat subsequently showed good memory as compared to objects for which the rat subsequently showed poor memory. The results showed a strong association between event-related gamma synchrony in rat hippocampus and memory encoding for novel objects. In addition, a novel potential mechanism of cross-frequency interactions was observed whereby dynamic alterations in the shape of theta wave related to memory in correspondence with the strength of gamma synchrony. These findings add to our understanding of how theta and gamma oscillations interact in the hippocampus in the service of memory.
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影响因子：
16.2
作者：
Carr MF;Karlsson MP;Frank LM
通讯作者：
Frank LM
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
2.9
作者：
Hasselmo, ME;Bodelón, C;Wyble, BP
通讯作者：
Wyble, BP
影响因子：
3.5
作者：
Buzsáki, G
通讯作者：
Buzsáki, G