Excitation/Inhibition Modulators in Autism Spectrum Disorder: Current Clinical Research.
Excitation/Inhibition Modulators in Autism Spectrum Disorder: Current Clinical Research.
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DOI：
10.3389/fnins.2021.753274
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发表时间：
2021
影响因子：
4.3
通讯作者：
Palumbi R
中科院分区：
文献类型：
--
作者：
Canitano R;Palumbi R
自闭症谱系障碍（ASD）是一组以社交和沟通异常为特征的神经发育障碍。核心和相关症状的表达和严重程度的异质性给分类和整体临床方法带来困难。在临床前ASD模型中观察到突触异常。它们被认为在临床功能异常中起主要作用，可能通过有针对性的干预来改变。兴奋性到抑制性神经传递的失衡（E/I失衡），分别通过谷氨酸能和gaba能神经传递的改变，被认为与ASD的发病机制有关。谷氨酸能和gaba能药物已经在临床试验中进行了测试，在疗效和耐受性方面取得了令人鼓舞的结果。需要进一步的研究来确认E/I调节剂在治疗ASD中的作用，以及目前药物的安全性和有效性。
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by social and communication abnormalities. Heterogeneity in the expression and severity of the core and associated symptoms poses difficulties in classification and the overall clinical approach. Synaptic abnormalities have been observed in preclinical ASD models. They are thought to play a major role in clinical functional abnormalities and might be modified by targeted interventions. An imbalance in excitatory to inhibitory neurotransmission (E/I imbalance), through altered glutamatergic and GABAergic neurotransmission, respectively, is thought to be implicated in the pathogenesis of ASD. Glutamatergic and GABAergic agents have been tested in clinical trials with encouraging results as to efficacy and tolerability. Further studies are needed to confirm the role of E/I modulators in the treatment of ASD and on the safety and efficacy of the current agents.
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