Head Movements Control the Activity of Primary Visual Cortex in a Luminance-Dependent Manner.
Head Movements Control the Activity of Primary Visual Cortex in a Luminance-Dependent Manner.
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DOI：
10.1016/j.neuron.2020.07.004
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发表时间：
2020-11-11
期刊：
影响因子：
16.2
通讯作者：
Scanziani M
中科院分区：
文献类型：
--
作者：
Bouvier G;Senzai Y;Scanziani M
前庭系统将与头部运动相关的信号广播到整个大脑的感觉区域，包括视觉皮层。这些信号对于大脑评估视觉场景的运动是否由动物的头部运动引起的能力至关重要。然而，头部运动如何影响视觉皮层回路仍然知之甚少。在这里，我们发现环境亮度深刻地改变了小鼠初级视觉皮层（V1）处理头部运动的方式。在黑暗中，头部运动会导致神经元活动的整体抑制，在环境光下，相同的头部运动会触发所有皮层的兴奋。这种V1处理头部运动的光依赖性开关是由生长抑素表达（SOM）抑制神经元控制的，这些神经元在黑暗中而不是在光照下受到头部运动的兴奋。因此，这项研究揭示了一个光依赖开关的响应V1头部运动，并确定了一个电路，其中SOM细胞是前庭和亮度信号的关键积分。前庭系统在整个大脑中传播与头部运动相关的信号。Bouvier等人表明，环境光影响初级视觉皮层（V1）对头部运动的反应。V1在黑暗中被头部运动所抑制，在光线中被头部运动所兴奋，这是通过生长抑素表达抑制神经元的差异募集来实现的。
The vestibular system broadcasts head-movement related signals to sensory areas throughout the brain, including visual cortex. These signals are crucial for the brain’s ability to assess whether motion of the visual scene results from the animal’s head-movements. How head-movements impact visual cortical circuits remains, however, poorly understood. Here, we discover that ambient luminance profoundly transforms how mouse primary visual cortex (V1) processes head-movements. While in darkness, head movements result in an overall suppression of neuronal activity, in ambient light the same head movements trigger excitation across all cortical layers. This light-dependent switch in how V1 processes head-movements is controlled by somatostatin-expressing (SOM) inhibitory neurons, which are excited by head movements in dark but not in light. This study thus reveals a light-dependent switch in the response of V1 to head-movements and identifies a circuit in which SOM cells are key integrators of vestibular and luminance signals. The vestibular system broadcasts head-movement related signals throughout the brain. Bouvier et al. show that ambient light impacts how primary visual cortex (V1) responds to head-movements. V1 is suppressed by head movements in darkness and excited by head-movements in light through the differential recruitment of somatostatin-expressing inhibitory neurons.
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