Serum uric acid levels and the risk of type 2 diabetes: a prospective study.
Serum uric acid levels and the risk of type 2 diabetes: a prospective study.
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DOI：
10.1016/j.amjmed.2010.03.027
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发表时间：
2010-10
影响因子：
5.9
通讯作者：
Choi, Hyon
中科院分区：
文献类型：
--
作者：
Bhole, Vidula;Choi, Jee Woong J.;Kim, Sung Woo;de Vera, Mary;Choi, Hyon
评估独立于其他因素的血尿酸水平对未来发生2型糖尿病风险的影响。我们使用弗雷明翰心脏研究原始(n=4,883)和后代(n=4,292)队列的前瞻性数据来检查血清尿酸水平与糖尿病发病率之间的关系。我们使用COX比例风险模型来估计发生糖尿病的相对风险(RR)，调整了年龄、性别、体力活动、饮酒、吸烟、高血压、体重指数以及血糖、胆固醇、肌酐和甘油三酯水平。我们确定了原始队列中的641例糖尿病病例和后代队列中的497例糖尿病病例。血尿酸水平及≥为8.0 mg/dL的原始队列和后代队列的糖尿病发病率分别为3.33、6.10、8.7、11.5、10.9和2.90、5.0、6.6、8.7、10.9(趋势与t；0.001的P值)。血尿酸水平每增加1 mg/dL，原始队列的多变量RRS为1.20(95%CI，1.11~1.28)，子代队列的多变量RRS为1.15(95%CI，1.06~1.23)。弗雷明翰心脏研究的两代人的这些前瞻性数据提供了证据，表明血清尿酸水平较高的个人，包括年轻人，未来患2型糖尿病的风险更高，而不受其他已知风险因素的影响。这些数据扩展了高尿酸血症和代谢综合征之间的横截面关联，并扩展了与未来2型糖尿病风险的联系。
To evaluate the impact of serum uric acid levels on the future risk of developing type 2 diabetes independent of other factors. We used prospective data from the Framingham Heart Study original (n=4,883) and offspring (n=4,292) cohorts to examine the association between serum uric acid levels and the incidence of diabetes. We used Cox proportional hazards models to estimate the relative risk (RR) of incident diabetes adjusting for age, sex, physical activity, alcohol consumption, smoking, hypertension, body mass index, and blood levels of glucose, cholesterol, creatinine, and triglycerides. We identified 641 incident cases of diabetes in the original cohort and 497 cases in the offspring cohort. The incidence rates of diabetes per 1000 person-years for serum uric acid levels <5.0, 5.0-5.9, 6.0-6.9, 7.0-7.9 and ≥8.0 mg/dL were 3.3, 6.1, 8.7, 11.5, and 15.9 in the original cohort, and 2.9, 5.0, 6.6, 8.7, 10.9 in the offspring cohort, respectively (P-values for trends <0.001). Multivariable RRs per mg/dL increase in serum uric acid levels were 1.20 (95% CI, 1.11 to 1.28) for the original cohort and 1.15 (95% CI, 1.06 to 1.23) for the offspring cohort. These prospective data from two generations of the Framingham Heart Study provide evidence that individuals with higher serum uric acid, including younger adults, are at a higher future risk of type 2 diabetes independent of other known risk factors. These data expand on cross-sectional associations between hyperuricemia and the metabolic syndrome, and extend the link to the future risk of type 2 diabetes.
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影响因子：
3.2
作者：
Muscelli, E;Natali, A;Ferrannini, E
通讯作者：
Ferrannini, E
影响因子：
64.8
作者：
Enomoto, A;Kimura, H;Endou, H
通讯作者：
Endou, H
影响因子：
7.7
作者：
Meigs, JB;Wilson, PWF;Haffner, SM
通讯作者：
Haffner, SM
影响因子：
5.9
作者：
Choi, Hyon K.;Ford, Earl S.
通讯作者：
Ford, Earl S.
影响因子：
--
作者：
KANNEL, WB;SORLIE, P
通讯作者：
SORLIE, P