Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography.
Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography.
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DOI：
10.1016/j.ajo.2011.03.008
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发表时间：
2011-10
影响因子：
4.2
通讯作者：
Duker, Jay S.
中科院分区：
文献类型：
--
作者：
Manjunath, Varsha;Goren, Jordana;Fujimoto, James G.;Duker, Jay S.
使用谱域光学相干断层扫描了解年龄相关性黄斑变性（AMD）患者脉络膜厚度与各种疾病因素之间的关系。横断面、回顾性分析。对 2009 年 11 月至 2010 年 1 月期间在马萨诸塞州波士顿新英格兰眼科中心就诊的 47 名湿性和干性 AMD 患者的 57 只眼睛进行了分析。脉络膜厚度由 2 名独立观察者在 11 个部位通过中央凹中心进行高清水平 1 线光栅扫描来测量。进行回顾性图表审查以获得有关疾病持续时间、玻璃体内抗血管内皮生长因子注射次数、视力、晶状体状态和伴随的视网膜病理特征的数据。使用 Pearson 相关性和 Student t 检验进行统计分析，以评估湿性和干性 AMD 的脉络膜厚度变化。患有湿性和干性 AMD 的眼睛中的脉络膜显示出高于和低于正常平均值的广泛厚度（范围，77.5 至 399.5 μm；标准差 [SD]，90.2）。近三分之一 (33.3%) 的 AMD 眼睛测量结果比平均值低不到 1 个标准差。湿性 AMD 眼睛的平均中心凹下脉络膜厚度为 194.6 μm（SD，88.4；n = 40），而干性 AMD 组的平均中心凹下脉络膜厚度为 213.4 μm（SD，92.2；n = 17）。干性 AMD 眼睛的脉络膜厚度与年龄成反比（r = -0.703；P = .002）；然而，对玻璃体内抗血管内皮生长因子注射次数、患病年数和视力的分析未能证明与脉络膜厚度有任何显着相关性。这项研究表明，脉络膜厚度可以通过谱域光学相干断层扫描来测量，并且临床诊断为湿性和干性AMD的患者中存在可变的脉络膜厚度。然而，目前尚不清楚为什么在某些眼睛中，脉络膜厚度会随着疾病而增加或减少。需要进行进一步的研究以了解脉络膜厚度对于视功能和疾病随时间进展的重要性。
To understand the relationship between choroidal thickness and various disease factors in patients with age-related macular degeneration (AMD) using spectral-domain optical coherence tomography. Cross-sectional, retrospective analysis. Fifty-seven eyes of 47 patients with wet and dry AMD seen between November 2009 and January 2010 at the New England Eye Center, Boston, Massachusetts, were analyzed. Choroidal thickness was measured by 2 independent observers at 11 sites with high-definition horizontal 1-line raster scans through the foveal center. A retrospective chart review was performed to obtain data concerning duration of disease, number of intravitreal anti–vascular endothelial growth factor injections, visual acuity, lens status, and concomitant retinal pathologic features. The Pearson correlation and Student t test were used for statistical analysis for assessment of choroidal thickness changes in wet and dry AMD. The choroid in eyes with wet and dry AMD demonstrated a wide range of thicknesses above and below the normal mean (range, 77.5 to 399.5 μm; standard deviation [SD], 90.2). Nearly one third (33.3%) of the eyes with AMD measured less than 1 SD below the mean. Eyes with wet AMD demonstrated a mean subfoveal choroidal thickness of 194.6 μm (SD, 88.4; n = 40) compared with 213.4 μm (SD, 92.2; n = 17) in the dry AMD group. The choroidal thickness in eyes with dry AMD was correlated inversely with age (r = −0.703; P = .002); however, analysis of the number of intravitreal anti–vascular endothelial growth factor injections, number of years of disease, and visual acuity failed to demonstrate any significant correlations with choroidal thickness. This study demonstrated that choroidal thickness can be measured by spectral-domain optical coherence tomography and that variable choroidal thickness exists among patients with the clinical diagnosis of wet and dry AMD. However, it is unclear at this time why in some eyes, choroidal thickness either increases or decreases with the disease. Further studies need to be carried out to understand the significance of choroidal thickness with respect to visual function and disease progression over time.
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影响因子：
3.4
作者：
Bhutto, Imran A.;Baba, Takayuki;Merges, Carol;McLeod, D. Scott;Lutty, Gerard A.
通讯作者：
Lutty, Gerard A.
影响因子：
4.4
作者：
Ikuno, Yasushi;Kawaguchi, Kana;Yasuno, Yoshiaki
通讯作者：
Yasuno, Yoshiaki
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
Imamura, Yutaka;Fujiwara, Takamitsu;Spaide, Richard F.
通讯作者：
Spaide, Richard F.
影响因子：
13.7
作者：
Kaiser, Peter K.;Blodi, Barbara A.;Acharya, Nisha R.
通讯作者：
Acharya, Nisha R.
影响因子：
4.4
作者：
Pournaras, CJ;Logean, E;Soubrane, G
通讯作者：
Soubrane, G