Lipid Nanoparticles Loaded with Iridoid Glycosides: Development and Optimization Using Experimental Factorial Design.
Lipid Nanoparticles Loaded with Iridoid Glycosides: Development and Optimization Using Experimental Factorial Design.
复制标题
DOI：
10.3390/molecules26113161
复制
发表时间：
2021-05-25
期刊：
影响因子：
--
通讯作者：
Nowak I
中科院分区：
文献类型：
--
作者：
Dąbrowska M;Souto EB;Nowak I
基于多重乳液（W/O/W）系统的脂质纳米粒适合于掺入亲水性活性物质，包括环烯醚萜苷。本研究涉及脂质纳米颗粒的组合物的优化，活性化合物（桃叶珊瑚苷和梓醇）的掺入，所得纳米载体的稳定性的评价，和其脂质基质的表征。基于32因子设计，脂质纳米粒的优化分散体（固体脂质：表面活性剂-4.5：1.0重量%）的开发，倾向于通过超声波处理法掺入环烯醚萜苷。活性物质的包封率测定为近90%（桃叶珊瑚苷）和77%（梓醇）。关于稳定性研究，发现室温最适合于维持预期的物理化学参数值（粒度< 100 nm;多分散指数< 0.3; ζ电位>| ± 30 mV|).脂质基质的表征证实了所得载体的纳米尺寸范围（低于100 nm），以及稳定β'形式的脂质的存在。
Lipid nanoparticles based on multiple emulsion (W/O/W) systems are suitable for incorporating hydrophilic active substances, including iridoid glycosides. This study involved optimization of composition of lipid nanoparticles, incorporation of active compounds (aucubin and catalpol), evaluation of stability of the resulting nanocarriers, and characterization of their lipid matrix. Based on 32 factorial design, an optimized dispersion of lipid nanoparticles (solid lipid:surfactant—4.5:1.0 wt.%) was developed, predisposed for the incorporation of iridoid glycosides by emulsification-sonication method. The encapsulation efficiency of the active substances was determined at nearly 90% (aucubin) and 77% (catalpol). Regarding the stability study, room temperature was found to be the most suitable for maintaining the expected physicochemical parameter values (particle size < 100 nm; polydispersity index < 0.3; zeta potential > |± 30 mV|). Characterization of the lipid matrix confirmed the nanometer size range of the resulting carriers (below 100 nm), as well as the presence of the lipid in the stable β’ form.
登录
查看更多内容
影响因子：
4.6
作者：
Krithika, Ramakrishnan;Srivastava, Prabhakar Lal;Thulasiram, Hirekodathakallu V.
通讯作者：
Thulasiram, Hirekodathakallu V.
影响因子：
5.8
作者：
Fangueiro, Joana F.;Andreani, Tatiana;Souto, Eliana B.
通讯作者：
Souto, Eliana B.
影响因子：
2.3
作者：
Estanqueiro, M.;Conceicao, J.;Sousa Lobo, J. M.
通讯作者：
Sousa Lobo, J. M.
影响因子：
10.8
作者：
Jores, K;Mehnert, W;Mäder, K
通讯作者：
Mäder, K
影响因子：
5.8
作者：
Fangueiro, Joana F.;Andreani, Tatiana;Souto, Eliana B.
通讯作者：
Souto, Eliana B.